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Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study: methods and challenges.

Publication ,  Journal Article
Hoest, C; Seidman, JC; Pan, W; Ambikapathi, R; Kang, G; Kosek, M; Knobler, S; Mason, CJ; Miller, M; MAL-ED Network Investigators
Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
November 2014

Most vaccine assessments have occurred in well-nourished populations of higher socioeconomic status. However, vaccines are often used in populations with high incidences of malnutrition and infections, in whom the effectiveness of some vaccines is inferior for unknown reasons. The degree and extent of vaccine underperformance have not been systematically studied for most vaccines across differing epidemiologic settings. This paper outlines the methods used and challenges associated with measuring immunological responses to oral vaccines against poliovirus and rotavirus, and parenteral vaccines against pertussis, tetanus, and measles in an observational study that monitored daily illness, monthly growth, intestinal inflammation and permeability, pathogen burden, dietary intake, and micronutrient status in children in 8 countries. This evaluation of vaccine response in the context of low- and middle-income countries is intended to address the gaps in knowledge of the heterogeneity in vaccine response in diverse epidemiological settings and the interplay between infections, nutrition, and immune response.

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Published In

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

EISSN

1537-6591

ISSN

1058-4838

Publication Date

November 2014

Volume

59 Suppl 4

Start / End Page

S273 / S279

Related Subject Headings

  • Vaccines
  • Microbiology
  • Malnutrition
  • Longitudinal Studies
  • Intestinal Diseases
  • Infant
  • Humans
  • Epidemiologic Research Design
  • Diarrhea
  • Child, Preschool
 

Citation

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Chicago
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MLA
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Hoest, C., Seidman, J. C., Pan, W., Ambikapathi, R., Kang, G., Kosek, M., … MAL-ED Network Investigators. (2014). Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study: methods and challenges. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 59 Suppl 4, S273–S279. https://doi.org/10.1093/cid/ciu611
Hoest, Christel, Jessica C. Seidman, William Pan, Ramya Ambikapathi, Gagandeep Kang, Margaret Kosek, Stacey Knobler, Carl J. Mason, Mark Miller, and MAL-ED Network Investigators. “Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study: methods and challenges.Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 59 Suppl 4 (November 2014): S273–79. https://doi.org/10.1093/cid/ciu611.
Hoest C, Seidman JC, Pan W, Ambikapathi R, Kang G, Kosek M, et al. Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study: methods and challenges. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2014 Nov;59 Suppl 4:S273–9.
Hoest, Christel, et al. “Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study: methods and challenges.Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, vol. 59 Suppl 4, Nov. 2014, pp. S273–79. Epmc, doi:10.1093/cid/ciu611.
Hoest C, Seidman JC, Pan W, Ambikapathi R, Kang G, Kosek M, Knobler S, Mason CJ, Miller M, MAL-ED Network Investigators. Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study: methods and challenges. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2014 Nov;59 Suppl 4:S273–S279.
Journal cover image

Published In

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

EISSN

1537-6591

ISSN

1058-4838

Publication Date

November 2014

Volume

59 Suppl 4

Start / End Page

S273 / S279

Related Subject Headings

  • Vaccines
  • Microbiology
  • Malnutrition
  • Longitudinal Studies
  • Intestinal Diseases
  • Infant
  • Humans
  • Epidemiologic Research Design
  • Diarrhea
  • Child, Preschool