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A synaptic and circuit basis for corollary discharge in the auditory cortex.

Publication ,  Journal Article
Schneider, DM; Nelson, A; Mooney, R
Published in: Nature
September 11, 2014

Sensory regions of the brain integrate environmental cues with copies of motor-related signals important for imminent and ongoing movements. In mammals, signals propagating from the motor cortex to the auditory cortex are thought to have a critical role in normal hearing and behaviour, yet the synaptic and circuit mechanisms by which these motor-related signals influence auditory cortical activity remain poorly understood. Using in vivo intracellular recordings in behaving mice, we find that excitatory neurons in the auditory cortex are suppressed before and during movement, owing in part to increased activity of local parvalbumin-positive interneurons. Electrophysiology and optogenetic gain- and loss-of-function experiments reveal that motor-related changes in auditory cortical dynamics are driven by a subset of neurons in the secondary motor cortex that innervate the auditory cortex and are active during movement. These findings provide a synaptic and circuit basis for the motor-related corollary discharge hypothesized to facilitate hearing and auditory-guided behaviours.

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Published In

Nature

DOI

EISSN

1476-4687

Publication Date

September 11, 2014

Volume

513

Issue

7517

Start / End Page

189 / 194

Location

England

Related Subject Headings

  • Sensory Receptor Cells
  • Optogenetics
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • General Science & Technology
  • Female
  • Electrical Synapses
  • Auditory Cortex
 

Citation

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Schneider, D. M., Nelson, A., & Mooney, R. (2014). A synaptic and circuit basis for corollary discharge in the auditory cortex. Nature, 513(7517), 189–194. https://doi.org/10.1038/nature13724
Schneider, David M., Anders Nelson, and Richard Mooney. “A synaptic and circuit basis for corollary discharge in the auditory cortex.Nature 513, no. 7517 (September 11, 2014): 189–94. https://doi.org/10.1038/nature13724.
Schneider DM, Nelson A, Mooney R. A synaptic and circuit basis for corollary discharge in the auditory cortex. Nature. 2014 Sep 11;513(7517):189–94.
Schneider, David M., et al. “A synaptic and circuit basis for corollary discharge in the auditory cortex.Nature, vol. 513, no. 7517, Sept. 2014, pp. 189–94. Pubmed, doi:10.1038/nature13724.
Schneider DM, Nelson A, Mooney R. A synaptic and circuit basis for corollary discharge in the auditory cortex. Nature. 2014 Sep 11;513(7517):189–194.

Published In

Nature

DOI

EISSN

1476-4687

Publication Date

September 11, 2014

Volume

513

Issue

7517

Start / End Page

189 / 194

Location

England

Related Subject Headings

  • Sensory Receptor Cells
  • Optogenetics
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • General Science & Technology
  • Female
  • Electrical Synapses
  • Auditory Cortex