Skip to main content

Antithrombotic therapy: new areas to understand efficacy and bleeding.

Publication ,  Journal Article
Wisler, JW; Becker, RC
Published in: Expert Opin Ther Targets
December 2014

INTRODUCTION: Therapeutic options for antithrombotic therapy are limited due to associated adverse bleeding events. Traditionally, the antithrombotic effects of these agents have been closely linked with concomitant risks in bleeding complications. AREAS COVERED: This article will review recent developments in the understanding of the mechanisms underlying physiological hemostasis and pathological thrombosis as well as key findings that may serve to 'uncouple' these two processes. In addition, we highlight the recent work identifying novel therapeutic agents targeting these novel mechanisms of pathological thrombus formation. EXPERT OPINION: Recent research has identified several novel mediators of thrombus formation, including cell-free nucleic acids, histones, histone-DNA complexes and neutrophil extracellular traps that may serve to link inflammation and thrombosis as well as separate physiological hemostasis from pathological thrombosis. Researchers are developing ligands to target these mediators with an achievable goal to identify novel therapies that inhibit thrombus formation without increased bleeding risk.

Duke Scholars

Published In

Expert Opin Ther Targets

DOI

EISSN

1744-7631

Publication Date

December 2014

Volume

18

Issue

12

Start / End Page

1427 / 1434

Location

England

Related Subject Headings

  • Treatment Outcome
  • Thrombosis
  • Oncology & Carcinogenesis
  • Humans
  • Hemorrhage
  • Fibrinolytic Agents
  • Comprehension
  • Blood Coagulation
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wisler, J. W., & Becker, R. C. (2014). Antithrombotic therapy: new areas to understand efficacy and bleeding. Expert Opin Ther Targets, 18(12), 1427–1434. https://doi.org/10.1517/14728222.2014.953929
Wisler, James W., and Richard C. Becker. “Antithrombotic therapy: new areas to understand efficacy and bleeding.Expert Opin Ther Targets 18, no. 12 (December 2014): 1427–34. https://doi.org/10.1517/14728222.2014.953929.
Wisler JW, Becker RC. Antithrombotic therapy: new areas to understand efficacy and bleeding. Expert Opin Ther Targets. 2014 Dec;18(12):1427–34.
Wisler, James W., and Richard C. Becker. “Antithrombotic therapy: new areas to understand efficacy and bleeding.Expert Opin Ther Targets, vol. 18, no. 12, Dec. 2014, pp. 1427–34. Pubmed, doi:10.1517/14728222.2014.953929.
Wisler JW, Becker RC. Antithrombotic therapy: new areas to understand efficacy and bleeding. Expert Opin Ther Targets. 2014 Dec;18(12):1427–1434.

Published In

Expert Opin Ther Targets

DOI

EISSN

1744-7631

Publication Date

December 2014

Volume

18

Issue

12

Start / End Page

1427 / 1434

Location

England

Related Subject Headings

  • Treatment Outcome
  • Thrombosis
  • Oncology & Carcinogenesis
  • Humans
  • Hemorrhage
  • Fibrinolytic Agents
  • Comprehension
  • Blood Coagulation
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences