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SnapShot: Mammalian Sirtuins.

Publication ,  Journal Article
Anderson, KA; Green, MF; Huynh, FK; Wagner, GR; Hirschey, MD
Published in: Cell
November 6, 2014

The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, and biological functions. This SnapShot provides an overview of these properties, with an emphasis on their relevance to aging.

Duke Scholars

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

November 6, 2014

Volume

159

Issue

4

Start / End Page

956 / 956.e1

Location

United States

Related Subject Headings

  • Sirtuins
  • Mitochondria
  • Mammals
  • Humans
  • Developmental Biology
  • Cell Nucleus
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Anderson, K. A., Green, M. F., Huynh, F. K., Wagner, G. R., & Hirschey, M. D. (2014). SnapShot: Mammalian Sirtuins. Cell, 159(4), 956-956.e1. https://doi.org/10.1016/j.cell.2014.10.045
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

November 6, 2014

Volume

159

Issue

4

Start / End Page

956 / 956.e1

Location

United States

Related Subject Headings

  • Sirtuins
  • Mitochondria
  • Mammals
  • Humans
  • Developmental Biology
  • Cell Nucleus
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences