SnapShot: Mammalian Sirtuins.
Publication
, Journal Article
Anderson, KA; Green, MF; Huynh, FK; Wagner, GR; Hirschey, MD
Published in: Cell
November 6, 2014
The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, and biological functions. This SnapShot provides an overview of these properties, with an emphasis on their relevance to aging.
Duke Scholars
Published In
Cell
DOI
EISSN
1097-4172
Publication Date
November 6, 2014
Volume
159
Issue
4
Start / End Page
956 / 956.e1
Location
United States
Related Subject Headings
- Sirtuins
- Mitochondria
- Mammals
- Humans
- Developmental Biology
- Cell Nucleus
- Animals
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Anderson, K. A., Green, M. F., Huynh, F. K., Wagner, G. R., & Hirschey, M. D. (2014). SnapShot: Mammalian Sirtuins. Cell, 159(4), 956-956.e1. https://doi.org/10.1016/j.cell.2014.10.045
Published In
Cell
DOI
EISSN
1097-4172
Publication Date
November 6, 2014
Volume
159
Issue
4
Start / End Page
956 / 956.e1
Location
United States
Related Subject Headings
- Sirtuins
- Mitochondria
- Mammals
- Humans
- Developmental Biology
- Cell Nucleus
- Animals
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences