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B cells in chronic graft-versus-host disease.

Publication ,  Journal Article
Sarantopoulos, S; Blazar, BR; Cutler, C; Ritz, J
Published in: Biol Blood Marrow Transplant
January 2015

Chronic graft-versus-host disease (cGVHD) continues to be a common complication of allogeneic hematopoietic stem cell transplantation. Unlike acute graft-versus-host disease, which is mediated almost entirely by donor T cells, the immune pathology of cGVHD is more complex and donor B cells have also been found to play an important role. Recent studies from several laboratories have enhanced our understanding of how donor B cells contribute to this clinical syndrome and this has led to new therapeutic opportunities. Here, Dr Sarantopoulos reviews some of the important mechanisms responsible for persistent B cell activation and loss of B cell tolerance in patients with cGVHD. Dr Blazar describes recent studies in preclinical models that have identified novel B cell-directed agents that may be effective for prevention or treatment of cGVHD. Some B cell-directed therapies have already been tested in patients with cGVHD and Dr Cutler reviews the results of these studies documenting the potential efficacy of this approach. Supported by mechanistic studies in patients and preclinical models, new B cell-directed therapies for cGVHD will now be evaluated in clinical trials.

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Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

January 2015

Volume

21

Issue

1

Start / End Page

16 / 23

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Rituximab
  • Mice
  • Lymphocyte Activation
  • Immunosuppressive Agents
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Hematologic Neoplasms
  • Graft vs Host Disease
 

Citation

APA
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ICMJE
MLA
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Sarantopoulos, S., Blazar, B. R., Cutler, C., & Ritz, J. (2015). B cells in chronic graft-versus-host disease. Biol Blood Marrow Transplant, 21(1), 16–23. https://doi.org/10.1016/j.bbmt.2014.10.029
Sarantopoulos, Stefanie, Bruce R. Blazar, Corey Cutler, and Jerome Ritz. “B cells in chronic graft-versus-host disease.Biol Blood Marrow Transplant 21, no. 1 (January 2015): 16–23. https://doi.org/10.1016/j.bbmt.2014.10.029.
Sarantopoulos S, Blazar BR, Cutler C, Ritz J. B cells in chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2015 Jan;21(1):16–23.
Sarantopoulos, Stefanie, et al. “B cells in chronic graft-versus-host disease.Biol Blood Marrow Transplant, vol. 21, no. 1, Jan. 2015, pp. 16–23. Pubmed, doi:10.1016/j.bbmt.2014.10.029.
Sarantopoulos S, Blazar BR, Cutler C, Ritz J. B cells in chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2015 Jan;21(1):16–23.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

January 2015

Volume

21

Issue

1

Start / End Page

16 / 23

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Rituximab
  • Mice
  • Lymphocyte Activation
  • Immunosuppressive Agents
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Hematologic Neoplasms
  • Graft vs Host Disease