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Personality and risk of Alzheimer's disease: new data and meta-analysis.

Publication ,  Journal Article
Terracciano, A; Sutin, AR; An, Y; O'Brien, RJ; Ferrucci, L; Zonderman, AB; Resnick, SM
Published in: Alzheimers Dement
March 2014

BACKGROUND: We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long-run longitudinal study and a meta-analysis of published studies. METHODS: Participants (n = 1671) were monitored for up to 22 years from a baseline personality assessment. The meta-analysis pooled results from up to five prospective studies (n = 5054). RESULTS: Individuals with scores in the top quartile of neuroticism (hazard ratio = 3.1; 95% confidence interval = 1.6-6.0) or the lowest quartile of conscientiousness (hazard ratio = 3.3; 95% confidence interval = 1.4-7.4) had a threefold increased risk of incident AD. Among the components of these traits, self-discipline and depression had the strongest associations with incident AD. The meta-analysis confirmed the associations of neuroticism (P = 2 × 10(-9)) and conscientiousness (P = 2 × 10(-6)), along with weaker effects for openness and agreeableness (P < .05). CONCLUSIONS: The current study and meta-analysis indicate that personality traits are associated with increased risk of AD, with effect sizes similar to those of well-established clinical and lifestyle risk factors.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

March 2014

Volume

10

Issue

2

Start / End Page

179 / 186

Location

United States

Related Subject Headings

  • Personality Inventory
  • Personality
  • Neuropsychological Tests
  • Middle Aged
  • Meta-Analysis as Topic
  • Male
  • Longitudinal Studies
  • Humans
  • Geriatrics
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Terracciano, A., Sutin, A. R., An, Y., O’Brien, R. J., Ferrucci, L., Zonderman, A. B., & Resnick, S. M. (2014). Personality and risk of Alzheimer's disease: new data and meta-analysis. Alzheimers Dement, 10(2), 179–186. https://doi.org/10.1016/j.jalz.2013.03.002
Terracciano, Antonio, Angelina R. Sutin, Yang An, Richard J. O’Brien, Luigi Ferrucci, Alan B. Zonderman, and Susan M. Resnick. “Personality and risk of Alzheimer's disease: new data and meta-analysis.Alzheimers Dement 10, no. 2 (March 2014): 179–86. https://doi.org/10.1016/j.jalz.2013.03.002.
Terracciano A, Sutin AR, An Y, O’Brien RJ, Ferrucci L, Zonderman AB, et al. Personality and risk of Alzheimer's disease: new data and meta-analysis. Alzheimers Dement. 2014 Mar;10(2):179–86.
Terracciano, Antonio, et al. “Personality and risk of Alzheimer's disease: new data and meta-analysis.Alzheimers Dement, vol. 10, no. 2, Mar. 2014, pp. 179–86. Pubmed, doi:10.1016/j.jalz.2013.03.002.
Terracciano A, Sutin AR, An Y, O’Brien RJ, Ferrucci L, Zonderman AB, Resnick SM. Personality and risk of Alzheimer's disease: new data and meta-analysis. Alzheimers Dement. 2014 Mar;10(2):179–186.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

March 2014

Volume

10

Issue

2

Start / End Page

179 / 186

Location

United States

Related Subject Headings

  • Personality Inventory
  • Personality
  • Neuropsychological Tests
  • Middle Aged
  • Meta-Analysis as Topic
  • Male
  • Longitudinal Studies
  • Humans
  • Geriatrics
  • Female