Skip to main content
Journal cover image

Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening.

Publication ,  Journal Article
Kilambi, V; Johnson, FR; González, JM; Mohamed, AF
Published in: Value Health
December 2014

BACKGROUND: The value of the information that genetic testing services provide can be questioned for insurance-based health systems. The results of genetic tests oftentimes may not lead to well-defined clinical interventions; however, Lynch syndrome, a genetic mutation for which carriers are at an increased risk for colorectal cancer, can be identified through genetic testing, and meaningful health interventions are available via increased colonoscopic surveillance. Valuations of test information for such conditions ought to account for the full impact of interventions and contingent outcomes. OBJECTIVES: To conduct a discrete-choice experiment to elicit individuals' preferences for genetic test information. METHODS: A Web-enabled discrete-choice experiment survey was administered to a representative sample of US residents aged 50 years and older. In addition to specifying expenditures on colonoscopies, respondents were asked to make a series of nine selections between two hypothetical genetic tests or a no-test option under the premise that a relative had Lynch syndrome. The hypothetical genetic tests were defined by the probability of developing colorectal cancer, the probability of a false-negative test result, privacy of the result, and out-of-pocket cost. A model specification identifying necessary interactions was derived from assumptions of risk behavior and the decision context and was estimated using random-parameters logit. RESULTS: A total of 650 respondents were contacted, and 385 completed the survey. The monetary equivalent of test information was approximately $1800. Expenditures on colonoscopies to reduce mortality risks affected valuations. Respondents with lower income or who reported being employed significantly valued genetic tests more. CONCLUSION: Genetic testing may confer benefits through the impact of subsequent interventions on private individuals.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Value Health

DOI

EISSN

1524-4733

Publication Date

December 2014

Volume

17

Issue

8

Start / End Page

838 / 845

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Sex Factors
  • Risk Assessment
  • Patient Preference
  • Models, Economic
  • Middle Aged
  • Male
  • Humans
  • Health Policy & Services
  • Genetic Testing
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kilambi, V., Johnson, F. R., González, J. M., & Mohamed, A. F. (2014). Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening. Value Health, 17(8), 838–845. https://doi.org/10.1016/j.jval.2014.09.001
Kilambi, Vikram, F Reed Johnson, Juan Marcos González, and Ateesha F. Mohamed. “Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening.Value Health 17, no. 8 (December 2014): 838–45. https://doi.org/10.1016/j.jval.2014.09.001.
Kilambi V, Johnson FR, González JM, Mohamed AF. Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening. Value Health. 2014 Dec;17(8):838–45.
Kilambi, Vikram, et al. “Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening.Value Health, vol. 17, no. 8, Dec. 2014, pp. 838–45. Pubmed, doi:10.1016/j.jval.2014.09.001.
Kilambi V, Johnson FR, González JM, Mohamed AF. Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening. Value Health. 2014 Dec;17(8):838–845.
Journal cover image

Published In

Value Health

DOI

EISSN

1524-4733

Publication Date

December 2014

Volume

17

Issue

8

Start / End Page

838 / 845

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Sex Factors
  • Risk Assessment
  • Patient Preference
  • Models, Economic
  • Middle Aged
  • Male
  • Humans
  • Health Policy & Services
  • Genetic Testing