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Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation.

Publication ,  Journal Article
Ballen, KK; Logan, BR; Laughlin, MJ; He, W; Ambruso, DR; Armitage, SE; Beddard, RL; Bhatla, D; Hwang, WYK; Kiss, JE; Koegler, G; Kurtzberg, J ...
Published in: Biol Blood Marrow Transplant
April 2015

Variations in cord blood manufacturing and administration are common, and the optimal practice is not known. We compared processing and banking practices at 16 public cord blood banks (CBB) in the United States and assessed transplantation outcomes on 530 single umbilical cord blood (UCB) myeloablative transplantations for hematologic malignancies facilitated by these banks. UCB banking practices were separated into 3 mutually exclusive groups based on whether processing was automated or manual, units were plasma and red blood cell reduced, or buffy coat production method or plasma reduced. Compared with the automated processing system for units, the day 28 neutrophil recovery was significantly lower after transplantation of units that were manually processed and plasma reduced (red cell replete) (odds ratio, .19; P = .001) or plasma and red cell reduced (odds ratio, .54; P = .05). Day 100 survival did not differ by CBB. However, day 100 survival was better with units that were thawed with the dextran-albumin wash method compared with the "no wash" or "dilution only" techniques (odds ratio, 1.82; P = .04). In conclusion, CBB processing has no significant effect on early (day 100) survival despite differences in kinetics of neutrophil recovery.

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Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

April 2015

Volume

21

Issue

4

Start / End Page

688 / 695

Location

United States

Related Subject Headings

  • Transplantation Conditioning
  • Male
  • Immunology
  • Humans
  • Hematopoietic Stem Cells
  • Female
  • Cord Blood Stem Cell Transplantation
  • Child, Preschool
  • Child
  • Allografts
 

Citation

APA
Chicago
ICMJE
MLA
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Ballen, K. K., Logan, B. R., Laughlin, M. J., He, W., Ambruso, D. R., Armitage, S. E., … Eapen, M. (2015). Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation. Biol Blood Marrow Transplant, 21(4), 688–695. https://doi.org/10.1016/j.bbmt.2014.12.017
Ballen, Karen K., Brent R. Logan, Mary J. Laughlin, Wensheng He, Daniel R. Ambruso, Susan E. Armitage, Rachel L. Beddard, et al. “Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation.Biol Blood Marrow Transplant 21, no. 4 (April 2015): 688–95. https://doi.org/10.1016/j.bbmt.2014.12.017.
Ballen KK, Logan BR, Laughlin MJ, He W, Ambruso DR, Armitage SE, et al. Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2015 Apr;21(4):688–95.
Ballen, Karen K., et al. “Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation.Biol Blood Marrow Transplant, vol. 21, no. 4, Apr. 2015, pp. 688–95. Pubmed, doi:10.1016/j.bbmt.2014.12.017.
Ballen KK, Logan BR, Laughlin MJ, He W, Ambruso DR, Armitage SE, Beddard RL, Bhatla D, Hwang WYK, Kiss JE, Koegler G, Kurtzberg J, Nagler A, Oh D, Petz LD, Price TH, Quinones RR, Ratanatharathorn V, Rizzo JD, Sazama K, Scaradavou A, Schuster MW, Sender LS, Shpall EJ, Spellman SR, Sutton M, Weitekamp LA, Wingard JR, Eapen M. Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2015 Apr;21(4):688–695.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

April 2015

Volume

21

Issue

4

Start / End Page

688 / 695

Location

United States

Related Subject Headings

  • Transplantation Conditioning
  • Male
  • Immunology
  • Humans
  • Hematopoietic Stem Cells
  • Female
  • Cord Blood Stem Cell Transplantation
  • Child, Preschool
  • Child
  • Allografts