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Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy.

Publication ,  Journal Article
Rosenblum, JM; Kirk, AD
Published in: Immunol Rev
March 2014

One's cellular immune repertoire is composed of lymphocytes in multiple stages of maturation - the dynamic product of their responses to antigenic challenges and the homeostatic contractions necessary to accommodate immune expansions within physiologic norms. Given that alloreactivity is predominantly a cross-reactive phenomenon that is stochastically distributed throughout the overall T-cell repertoire, one's allospecific repertoire is similarly made up of cells in a variety of differentiation states. As such, the continuous expansion and elimination of activated memory populations, producing a 'recollective homeostasis' of sorts, has the potential over time to alter the maturation state and effector composition of both ones protective and alloreactive T-cell repertoire. Importantly, a T cell's maturation state significantly influences its response to numerous immunomodulatory therapies used in organ transplantation, including depletional antibody induction. In this review, we discuss clinically utilized depletional induction strategies, how their use alters a transplant recipient's cellular immune repertoire, and how a recipient's repertoire influences the clinical effects of induction therapy.

Duke Scholars

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

March 2014

Volume

258

Issue

1

Start / End Page

167 / 182

Location

England

Related Subject Headings

  • Treatment Outcome
  • Transplantation Tolerance
  • T-Lymphocytes
  • Organ Transplantation
  • Lymphocyte Depletion
  • Immunosuppressive Agents
  • Immunology
  • Immunologic Memory
  • Immunity, Cellular
  • Humans
 

Citation

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ICMJE
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Rosenblum, J. M., & Kirk, A. D. (2014). Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy. Immunol Rev, 258(1), 167–182. https://doi.org/10.1111/imr.12155
Rosenblum, Joshua M., and Allan D. Kirk. “Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy.Immunol Rev 258, no. 1 (March 2014): 167–82. https://doi.org/10.1111/imr.12155.
Rosenblum, Joshua M., and Allan D. Kirk. “Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy.Immunol Rev, vol. 258, no. 1, Mar. 2014, pp. 167–82. Pubmed, doi:10.1111/imr.12155.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

March 2014

Volume

258

Issue

1

Start / End Page

167 / 182

Location

England

Related Subject Headings

  • Treatment Outcome
  • Transplantation Tolerance
  • T-Lymphocytes
  • Organ Transplantation
  • Lymphocyte Depletion
  • Immunosuppressive Agents
  • Immunology
  • Immunologic Memory
  • Immunity, Cellular
  • Humans