Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.
Publication
, Journal Article
Weaver, TA; Charafeddine, AH; Agarwal, A; Turner, AP; Russell, M; Leopardi, FV; Kampen, RL; Stempora, L; Song, M; Larsen, CP; Kirk, AD
Published in: Nat Med
July 2009
Memory T cells promote allograft rejection particularly in co-stimulation blockade-based immunosuppressive regimens. Here we show that the CD2-specific fusion protein alefacept (lymphocyte function-associated antigen-3-Ig; LFA -3-Ig) selectively eliminates memory T cells and, when combined with a co-stimulation blockade-based regimen using cytotoxic T lymphocyte antigen-4 (CTLA-4)-Ig, a CD80- and CD86-specific fusion protein, prevents renal allograft rejection and alloantibody formation in nonhuman primates. These results support the immediate translation of a regimen for the prevention of allograft rejection without the use of calcineurin inhibitors, steroids or pan-T cell depletion.
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Published In
Nat Med
DOI
EISSN
1546-170X
Publication Date
July 2009
Volume
15
Issue
7
Start / End Page
746 / 749
Location
United States
Related Subject Headings
- Transplantation, Homologous
- T-Lymphocytes
- Sirolimus
- Recombinant Fusion Proteins
- Macaca mulatta
- Kidney Transplantation
- Immunology
- Immunologic Memory
- Immunoconjugates
- Graft Survival
Citation
APA
Chicago
ICMJE
MLA
NLM
Weaver, T. A., Charafeddine, A. H., Agarwal, A., Turner, A. P., Russell, M., Leopardi, F. V., … Kirk, A. D. (2009). Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates. Nat Med, 15(7), 746–749. https://doi.org/10.1038/nm.1993
Weaver, Tim A., Ali H. Charafeddine, Avinash Agarwal, Alexandra P. Turner, Maria Russell, Frank V. Leopardi, Robert L. Kampen, et al. “Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.” Nat Med 15, no. 7 (July 2009): 746–49. https://doi.org/10.1038/nm.1993.
Weaver TA, Charafeddine AH, Agarwal A, Turner AP, Russell M, Leopardi FV, et al. Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates. Nat Med. 2009 Jul;15(7):746–9.
Weaver, Tim A., et al. “Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.” Nat Med, vol. 15, no. 7, July 2009, pp. 746–49. Pubmed, doi:10.1038/nm.1993.
Weaver TA, Charafeddine AH, Agarwal A, Turner AP, Russell M, Leopardi FV, Kampen RL, Stempora L, Song M, Larsen CP, Kirk AD. Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates. Nat Med. 2009 Jul;15(7):746–749.
Published In
Nat Med
DOI
EISSN
1546-170X
Publication Date
July 2009
Volume
15
Issue
7
Start / End Page
746 / 749
Location
United States
Related Subject Headings
- Transplantation, Homologous
- T-Lymphocytes
- Sirolimus
- Recombinant Fusion Proteins
- Macaca mulatta
- Kidney Transplantation
- Immunology
- Immunologic Memory
- Immunoconjugates
- Graft Survival