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Obesity following kidney transplantation and steroid avoidance immunosuppression.

Publication ,  Journal Article
Elster, EA; Leeser, DB; Morrissette, C; Pepek, JM; Quiko, A; Hale, DA; Chamberlain, C; Salaita, C; Kirk, AD; Mannon, RB
Published in: Clin Transplant
2008

Obesity is an important co-morbidity within end-stage renal disease (ESRD) and renal transplant populations. Previous studies have suggested that chronic corticosteroids result in increased body weight post-transplant. With the recent adoption of steroid-sparing immunosuppressive strategies, we evaluated the effect of these strategies on body mass index (BMI) after renal transplantation. We examined 95 renal transplant recipients enrolled in National Institutes of Health clinical transplant trials over the past three yr who received either lymphocyte depletion-based steroid sparing or traditional immunosuppressive therapy that included steroids for maintenance immunosuppression. Recipients were overweight prior to transplant and no significant differences existed in pre-transplant BMI among treatment groups. Regardless of therapy, BMI increased post-transplant in all recipients. The BMI increase consisted of an average weight gain of 5.01 +/- 7.12 kg (mean, SD) post-transplant. Additionally, in a number of recipients placed on maintenance steroids, subsequent withdrawal at a mean of 100 d post-transplant had no impact on weight gain. Thus, body weight and BMI increase following kidney transplantation, even in the absence of steroids. Thus, patients gain weight after renal transplantation regardless of the treatment strategy. Steroid avoidance alone does not reduce risk factors associated with obesity in our patient population.

Duke Scholars

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

2008

Volume

22

Issue

3

Start / End Page

354 / 359

Location

Denmark

Related Subject Headings

  • Tacrolimus
  • Surgery
  • Steroids
  • Sirolimus
  • Risk Factors
  • Obesity
  • Mycophenolic Acid
  • Middle Aged
  • Male
  • Kidney Transplantation
 

Citation

APA
Chicago
ICMJE
MLA
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Elster, E. A., Leeser, D. B., Morrissette, C., Pepek, J. M., Quiko, A., Hale, D. A., … Mannon, R. B. (2008). Obesity following kidney transplantation and steroid avoidance immunosuppression. Clin Transplant, 22(3), 354–359. https://doi.org/10.1111/j.1399-0012.2008.00792.x
Elster, Eric A., David B. Leeser, Craig Morrissette, Joseph M. Pepek, Albin Quiko, Douglas A. Hale, Christine Chamberlain, Christine Salaita, Allan D. Kirk, and Roslyn B. Mannon. “Obesity following kidney transplantation and steroid avoidance immunosuppression.Clin Transplant 22, no. 3 (2008): 354–59. https://doi.org/10.1111/j.1399-0012.2008.00792.x.
Elster EA, Leeser DB, Morrissette C, Pepek JM, Quiko A, Hale DA, et al. Obesity following kidney transplantation and steroid avoidance immunosuppression. Clin Transplant. 2008;22(3):354–9.
Elster, Eric A., et al. “Obesity following kidney transplantation and steroid avoidance immunosuppression.Clin Transplant, vol. 22, no. 3, 2008, pp. 354–59. Pubmed, doi:10.1111/j.1399-0012.2008.00792.x.
Elster EA, Leeser DB, Morrissette C, Pepek JM, Quiko A, Hale DA, Chamberlain C, Salaita C, Kirk AD, Mannon RB. Obesity following kidney transplantation and steroid avoidance immunosuppression. Clin Transplant. 2008;22(3):354–359.
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

2008

Volume

22

Issue

3

Start / End Page

354 / 359

Location

Denmark

Related Subject Headings

  • Tacrolimus
  • Surgery
  • Steroids
  • Sirolimus
  • Risk Factors
  • Obesity
  • Mycophenolic Acid
  • Middle Aged
  • Male
  • Kidney Transplantation