Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth.

Publication ,  Journal Article
Zhou, W; Ke, SQ; Huang, Z; Flavahan, W; Fang, X; Paul, J; Wu, L; Sloan, AE; McLendon, RE; Li, X; Rich, JN; Bao, S
Published in: Nat Cell Biol
February 2015

Tumour-associated macrophages (TAMs) are enriched in glioblastoma multiformes (GBMs) that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation between TAM density and glioma grade suggests a supportive role for TAMs in tumour progression. Here we interrogated the molecular link between GSCs and TAM recruitment in GBMs and demonstrated that GSCs secrete periostin (POSTN) to recruit TAMs. TAM density correlates with POSTN levels in human GBMs. Silencing POSTN in GSCs markedly reduced TAM density, inhibited tumour growth, and increased survival of mice bearing GSC-derived xenografts. We found that TAMs in GBMs are not brain-resident microglia, but mainly monocyte-derived macrophages from peripheral blood. Disrupting POSTN specifically attenuated the tumour-supportive M2 type of TAMs in xenografts. POSTN recruits TAMs through the integrin αvβ₃ as blocking this signalling by an RGD peptide inhibited TAM recruitment. Our findings highlight the possibility of improving GBM treatment by targeting POSTN-mediated TAM recruitment.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Cell Biol

DOI

EISSN

1476-4679

Publication Date

February 2015

Volume

17

Issue

2

Start / End Page

170 / 182

Location

England

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Survival Analysis
  • Signal Transduction
  • RNA, Small Interfering
  • Neoplastic Stem Cells
  • Monocytes
  • Mice, Inbred C57BL
  • Macrophages
  • Luminescent Measurements
  • Integrin alphaVbeta3
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhou, W., Ke, S. Q., Huang, Z., Flavahan, W., Fang, X., Paul, J., … Bao, S. (2015). Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol, 17(2), 170–182. https://doi.org/10.1038/ncb3090
Zhou, Wenchao, Susan Q. Ke, Zhi Huang, William Flavahan, Xiaoguang Fang, Jeremy Paul, Ling Wu, et al. “Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth.Nat Cell Biol 17, no. 2 (February 2015): 170–82. https://doi.org/10.1038/ncb3090.
Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol. 2015 Feb;17(2):170–82.
Zhou, Wenchao, et al. “Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth.Nat Cell Biol, vol. 17, no. 2, Feb. 2015, pp. 170–82. Pubmed, doi:10.1038/ncb3090.
Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, Wu L, Sloan AE, McLendon RE, Li X, Rich JN, Bao S. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol. 2015 Feb;17(2):170–182.

Published In

Nat Cell Biol

DOI

EISSN

1476-4679

Publication Date

February 2015

Volume

17

Issue

2

Start / End Page

170 / 182

Location

England

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Survival Analysis
  • Signal Transduction
  • RNA, Small Interfering
  • Neoplastic Stem Cells
  • Monocytes
  • Mice, Inbred C57BL
  • Macrophages
  • Luminescent Measurements
  • Integrin alphaVbeta3