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The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus.

Publication ,  Journal Article
Friedman, J; Twyford, AD; Willis, JH; Blackman, BK
Published in: Molecular ecology
January 2015

Differential natural selection acting on populations in contrasting environments often results in adaptive divergence in multivariate phenotypes. Multivariate trait divergence across populations could be caused by selection on pleiotropic alleles or through many independent loci with trait-specific effects. Here, we assess patterns of association between a suite of traits contributing to life history divergence in the common monkey flower, Mimulus guttatus, and examine the genetic architecture underlying these correlations. A common garden survey of 74 populations representing annual and perennial strategies from across the native range revealed strong correlations between vegetative and reproductive traits. To determine whether these multitrait patterns arise from pleiotropic or independent loci, we mapped QTLs using an approach combining high-throughput sequencing with bulk segregant analysis on a cross between populations with divergent life histories. We find extensive pleiotropy for QTLs related to flowering time and stolon production, a key feature of the perennial strategy. Candidate genes related to axillary meristem development colocalize with the QTLs in a manner consistent with either pleiotropic or independent QTL effects. Further, these results are analogous to previous work showing pleiotropy-mediated genetic correlations within a single population of M. guttatus experiencing heterogeneous selection. Our findings of strong multivariate trait associations and pleiotropic QTLs suggest that patterns of genetic variation may determine the trajectory of adaptive divergence.

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Published In

Molecular ecology

DOI

EISSN

1365-294X

ISSN

0962-1083

Publication Date

January 2015

Volume

24

Issue

1

Start / End Page

111 / 122

Related Subject Headings

  • Sequence Analysis, DNA
  • Selection, Genetic
  • Quantitative Trait Loci
  • Phenotype
  • North America
  • Mimulus
  • High-Throughput Nucleotide Sequencing
  • Genetics, Population
  • Genetic Pleiotropy
  • Flowers
 

Citation

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Friedman, J., Twyford, A. D., Willis, J. H., & Blackman, B. K. (2015). The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus. Molecular Ecology, 24(1), 111–122. https://doi.org/10.1111/mec.13004
Friedman, Jannice, Alex D. Twyford, John H. Willis, and Benjamin K. Blackman. “The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus.Molecular Ecology 24, no. 1 (January 2015): 111–22. https://doi.org/10.1111/mec.13004.
Friedman J, Twyford AD, Willis JH, Blackman BK. The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus. Molecular ecology. 2015 Jan;24(1):111–22.
Friedman, Jannice, et al. “The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus.Molecular Ecology, vol. 24, no. 1, Jan. 2015, pp. 111–22. Epmc, doi:10.1111/mec.13004.
Friedman J, Twyford AD, Willis JH, Blackman BK. The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus. Molecular ecology. 2015 Jan;24(1):111–122.
Journal cover image

Published In

Molecular ecology

DOI

EISSN

1365-294X

ISSN

0962-1083

Publication Date

January 2015

Volume

24

Issue

1

Start / End Page

111 / 122

Related Subject Headings

  • Sequence Analysis, DNA
  • Selection, Genetic
  • Quantitative Trait Loci
  • Phenotype
  • North America
  • Mimulus
  • High-Throughput Nucleotide Sequencing
  • Genetics, Population
  • Genetic Pleiotropy
  • Flowers