Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease.

Publication ,  Journal Article
Navar-Boggan, AM; Peterson, ED; D'Agostino, RB; Neely, B; Sniderman, AD; Pencina, MJ
Published in: Circulation
February 3, 2015

BACKGROUND: Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-year cardiovascular risk. We evaluated the association between years of exposure to hypercholesterolemia in early adulthood and future coronary heart disease (CHD) risk. METHODS AND RESULTS: We examined Framingham Offspring Cohort data to identify adults without incident cardiovascular disease to 55 years of age (n=1478), and explored the association between duration of moderate hyperlipidemia (non-high-density lipoprotein cholesterol ≥ 160 mg/dL) in early adulthood and subsequent CHD. At median 15-year follow-up, CHD rates were significantly elevated among adults with prolonged hyperlipidemia exposure by 55 years of age: 4.4% for those with no exposure, 8.1% for those with 1 to 10 years of exposure, and 16.5% for those with 11 to 20 years of exposure (P<0.001); this association persisted after adjustment for other cardiac risk factors including non-high-density lipoprotein cholesterol at 55 years of age (hazard ratio, 1.39; 95% confidence interval, 1.05-1.85 per decade of hyperlipidemia). Overall, 85% of young adults with prolonged hyperlipidemia would not have been recommended for statin therapy at 40 years of age under current national guidelines. However, among those not considered statin therapy candidates at 55 years of age, there remained a significant association between cumulative exposure to hyperlipidemia in young adulthood and subsequent CHD risk (adjusted hazard ratio, 1.67; 95% confidence interval, 1.06-2.64). CONCLUSIONS: Cumulative exposure to hyperlipidemia in young adulthood increases the subsequent risk of CHD in a dose-dependent fashion. Adults with prolonged exposure to even moderate elevations in non-high-density lipoprotein cholesterol have elevated risk for future CHD and may benefit from more aggressive primary prevention.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

February 3, 2015

Volume

131

Issue

5

Start / End Page

451 / 458

Location

United States

Related Subject Headings

  • Time Factors
  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Hyperlipidemias
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Navar-Boggan, A. M., Peterson, E. D., D’Agostino, R. B., Neely, B., Sniderman, A. D., & Pencina, M. J. (2015). Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease. Circulation, 131(5), 451–458. https://doi.org/10.1161/CIRCULATIONAHA.114.012477
Navar-Boggan, Ann Marie, Eric D. Peterson, Ralph B. D’Agostino, Benjamin Neely, Allan D. Sniderman, and Michael J. Pencina. “Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease.Circulation 131, no. 5 (February 3, 2015): 451–58. https://doi.org/10.1161/CIRCULATIONAHA.114.012477.
Navar-Boggan AM, Peterson ED, D’Agostino RB, Neely B, Sniderman AD, Pencina MJ. Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease. Circulation. 2015 Feb 3;131(5):451–8.
Navar-Boggan, Ann Marie, et al. “Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease.Circulation, vol. 131, no. 5, Feb. 2015, pp. 451–58. Pubmed, doi:10.1161/CIRCULATIONAHA.114.012477.
Navar-Boggan AM, Peterson ED, D’Agostino RB, Neely B, Sniderman AD, Pencina MJ. Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease. Circulation. 2015 Feb 3;131(5):451–458.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

February 3, 2015

Volume

131

Issue

5

Start / End Page

451 / 458

Location

United States

Related Subject Headings

  • Time Factors
  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Hyperlipidemias
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Follow-Up Studies
  • Female