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AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.

Publication ,  Journal Article
Chen, D; Coffman, TM
Published in: Curr Opin Pharmacol
April 2015

Angiotensin type 1 (AT1) receptors are key effector elements of the renin-angiotensin system, mediating virtually all of the classical physiological actions of angiotensin II. Pharmacological blockade of the AT1 receptor effectively lowers blood pressure in a substantial proportion of patients with hypertension, indicating the pivotal role of these receptors in human hypertension. AT1 receptors are expressed in many different organ systems where they have myriad cellular actions. However, several lines of evidence have suggested that direct actions of AT1 receptors in kidney have a major role in regulation of blood pressure and in the pathogenesis of hypertension. Here we review recent studies suggesting that renal epithelium and vasculature may be key cellular targets, where AT1 receptor activation has powerful physiological impact. We will also examine novel regulatory mechanisms by peptides associated with the C-terminus of the AT1 receptor.

Duke Scholars

Published In

Curr Opin Pharmacol

DOI

EISSN

1471-4973

Publication Date

April 2015

Volume

21

Start / End Page

122 / 126

Location

England

Related Subject Headings

  • Renin-Angiotensin System
  • Receptor, Angiotensin, Type 1
  • Pharmacology & Pharmacy
  • Kidney
  • Hypertension
  • Humans
  • Epithelium
  • Blood Pressure
  • Animals
  • Adaptor Proteins, Signal Transducing
 

Citation

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Chen, D., & Coffman, T. M. (2015). AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation. Curr Opin Pharmacol, 21, 122–126. https://doi.org/10.1016/j.coph.2015.01.006
Chen, Daian, and Thomas M. Coffman. “AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.Curr Opin Pharmacol 21 (April 2015): 122–26. https://doi.org/10.1016/j.coph.2015.01.006.
Chen, Daian, and Thomas M. Coffman. “AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.Curr Opin Pharmacol, vol. 21, Apr. 2015, pp. 122–26. Pubmed, doi:10.1016/j.coph.2015.01.006.
Chen D, Coffman TM. AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation. Curr Opin Pharmacol. 2015 Apr;21:122–126.
Journal cover image

Published In

Curr Opin Pharmacol

DOI

EISSN

1471-4973

Publication Date

April 2015

Volume

21

Start / End Page

122 / 126

Location

England

Related Subject Headings

  • Renin-Angiotensin System
  • Receptor, Angiotensin, Type 1
  • Pharmacology & Pharmacy
  • Kidney
  • Hypertension
  • Humans
  • Epithelium
  • Blood Pressure
  • Animals
  • Adaptor Proteins, Signal Transducing