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Using age- and sex-specific risk thresholds to guide statin therapy: one size may not fit all.

Publication ,  Journal Article
Navar-Boggan, AM; Peterson, ED; D'Agostino, RB; Pencina, MJ; Sniderman, AD
Published in: J Am Coll Cardiol
April 28, 2015

BACKGROUND: New cholesterol guidelines emphasize 10-year risk of cardiovascular disease (CVD) to identify adults eligible for statin therapy as primary prevention. Whether these CVD risk thresholds should be individualized by age and sex has not been explored. OBJECTIVES: This study evaluated the potential impact of incorporating age- and sex-specific CVD risk thresholds into current cholesterol guidelines. METHODS: Using data from the Framingham Offspring Study, this study assessed current treatment recommendations among age- and sex-specific groups in 3,685 participants free of CVD. Then, it evaluated how varying age- and sex-specific 10-year CVD risk thresholds for statin treatment affect the sensitivity and specificity for incident 10-year CVD events. RESULTS: Basing statin therapy recommendations on a 10-year fixed risk threshold of 7.5% results in lower statin consideration among women than men (63% vs. 33%; p<0.0001), yet most of the study participants who were 66 to 75 years of age were recommended for statin treatment (90.3%). The fixed 7.5% threshold had relatively low sensitivity for capturing 10-year events in younger women and men (40 to 55 years of age). Sensitivity of the recommendations was substantially improved when the treatment threshold was reduced to 5% in participants who were 40 to 55 years of age. Among older adults (66 to 75 years of age), specificity was poor, but when the treatment threshold was raised to 10% in women and 15% in men, specificity significantly improved, with minimal loss in sensitivity. CONCLUSIONS: Cholesterol treatment recommendations could be improved by using individualized age- and sex-specific CVD risk thresholds.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

April 28, 2015

Volume

65

Issue

16

Start / End Page

1633 / 1639

Location

United States

Related Subject Headings

  • Sex Factors
  • Sensitivity and Specificity
  • Middle Aged
  • Male
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Guidelines as Topic
  • Female
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
 

Citation

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Navar-Boggan, A. M., Peterson, E. D., D’Agostino, R. B., Pencina, M. J., & Sniderman, A. D. (2015). Using age- and sex-specific risk thresholds to guide statin therapy: one size may not fit all. J Am Coll Cardiol, 65(16), 1633–1639. https://doi.org/10.1016/j.jacc.2015.02.025
Navar-Boggan, Ann Marie, Eric D. Peterson, Ralph B. D’Agostino, Michael J. Pencina, and Allan D. Sniderman. “Using age- and sex-specific risk thresholds to guide statin therapy: one size may not fit all.J Am Coll Cardiol 65, no. 16 (April 28, 2015): 1633–39. https://doi.org/10.1016/j.jacc.2015.02.025.
Navar-Boggan AM, Peterson ED, D’Agostino RB, Pencina MJ, Sniderman AD. Using age- and sex-specific risk thresholds to guide statin therapy: one size may not fit all. J Am Coll Cardiol. 2015 Apr 28;65(16):1633–9.
Navar-Boggan, Ann Marie, et al. “Using age- and sex-specific risk thresholds to guide statin therapy: one size may not fit all.J Am Coll Cardiol, vol. 65, no. 16, Apr. 2015, pp. 1633–39. Pubmed, doi:10.1016/j.jacc.2015.02.025.
Navar-Boggan AM, Peterson ED, D’Agostino RB, Pencina MJ, Sniderman AD. Using age- and sex-specific risk thresholds to guide statin therapy: one size may not fit all. J Am Coll Cardiol. 2015 Apr 28;65(16):1633–1639.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

April 28, 2015

Volume

65

Issue

16

Start / End Page

1633 / 1639

Location

United States

Related Subject Headings

  • Sex Factors
  • Sensitivity and Specificity
  • Middle Aged
  • Male
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Guidelines as Topic
  • Female
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases