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A confidence ellipse for the Net Reclassification Improvement.

Publication ,  Journal Article
Mühlenbruch, K; Kuxhaus, O; Pencina, MJ; Boeing, H; Liero, H; Schulze, MB
Published in: Eur J Epidemiol
April 2015

The Net Reclassification Improvement (NRI) has become a popular metric for evaluating improvement in disease prediction models through the past years. The concept is relatively straightforward but usage and interpretation has been different across studies. While no thresholds exist for evaluating the degree of improvement, many studies have relied solely on the significance of the NRI estimate. However, recent studies recommend that statistical testing with the NRI should be avoided. We propose using confidence ellipses around the estimated values of event and non-event NRIs which might provide the best measure of variability around the point estimates. Our developments are illustrated using practical examples from EPIC-Potsdam study.

Duke Scholars

Published In

Eur J Epidemiol

DOI

EISSN

1573-7284

Publication Date

April 2015

Volume

30

Issue

4

Start / End Page

299 / 304

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Predictive Value of Tests
  • Models, Statistical
  • Middle Aged
  • Male
  • Humans
  • Female
  • Epidemiology
  • Data Interpretation, Statistical
 

Citation

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ICMJE
MLA
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Mühlenbruch, K., Kuxhaus, O., Pencina, M. J., Boeing, H., Liero, H., & Schulze, M. B. (2015). A confidence ellipse for the Net Reclassification Improvement. Eur J Epidemiol, 30(4), 299–304. https://doi.org/10.1007/s10654-015-0001-1
Mühlenbruch, Kristin, Olga Kuxhaus, Michael J. Pencina, Heiner Boeing, Hannelore Liero, and Matthias B. Schulze. “A confidence ellipse for the Net Reclassification Improvement.Eur J Epidemiol 30, no. 4 (April 2015): 299–304. https://doi.org/10.1007/s10654-015-0001-1.
Mühlenbruch K, Kuxhaus O, Pencina MJ, Boeing H, Liero H, Schulze MB. A confidence ellipse for the Net Reclassification Improvement. Eur J Epidemiol. 2015 Apr;30(4):299–304.
Mühlenbruch, Kristin, et al. “A confidence ellipse for the Net Reclassification Improvement.Eur J Epidemiol, vol. 30, no. 4, Apr. 2015, pp. 299–304. Pubmed, doi:10.1007/s10654-015-0001-1.
Mühlenbruch K, Kuxhaus O, Pencina MJ, Boeing H, Liero H, Schulze MB. A confidence ellipse for the Net Reclassification Improvement. Eur J Epidemiol. 2015 Apr;30(4):299–304.
Journal cover image

Published In

Eur J Epidemiol

DOI

EISSN

1573-7284

Publication Date

April 2015

Volume

30

Issue

4

Start / End Page

299 / 304

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Predictive Value of Tests
  • Models, Statistical
  • Middle Aged
  • Male
  • Humans
  • Female
  • Epidemiology
  • Data Interpretation, Statistical