Scholars@Duke

Patient-reported outcomes as end points and outcome indicators in solid tumours.

Publication ,  Journal Article
Secord, AA; Coleman, RL; Havrilesky, LJ; Abernethy, AP; Samsa, GP; Cella, D
Published in: Nat Rev Clin Oncol
June 2015
Published version (DOI) Link to item

Patient-reported outcome (PRO) measures, such as quality of life, have been associated with relevant clinical end points and are prognostic for survival outcomes in a variety of solid cancers in adults. In the past few years, PROs have garnered a greater influence as established and clinically relevant measures that could alter the current paradigm of practice-changing therapeutic advances, as it has been recognized that classic clinical end points do not accurately portray a full appreciation of the benefits, risks and costs of therapy. In this Review, we comprehensively assess the correlation of PROs with treatment response and survival, and explore tumour-related and patient-centric composite end points in patients with cancer participating in clinical trials. Comparisons or composite end points that consider tumour-related and PRO components might help health-care providers, patients with cancer and decision makers to better understand the total clinical benefit of therapeutic interventions.

Duke Scholars

Angeles Alvarez Secord
Author Angeles Alvarez Secord Obstetrics and Gynecology, Gynecologic Oncology
Laura Jean Havrilesky
Author Laura Jean Havrilesky Obstetrics and Gynecology, Gynecologic Oncology
Gregory P. Samsa
Author Gregory P. Samsa Biostatistics & Bioinformatics, Division of Biostatistics

Published In

Nat Rev Clin Oncol

DOI

10.1038/nrclinonc.2015.29

EISSN

1759-4782

Publication Date

June 2015

Volume

12

Issue

6

Start / End Page

358 / 370

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Self Report
  • Quality of Life
  • Patient-Centered Care
  • Patient Outcome Assessment
  • Neoplasms
  • Humans
  • Forecasting
  • Clinical Trials as Topic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Secord, A. A., Coleman, R. L., Havrilesky, L. J., Abernethy, A. P., Samsa, G. P., & Cella, D. (2015). Patient-reported outcomes as end points and outcome indicators in solid tumours. Nat Rev Clin Oncol, 12(6), 358–370. https://doi.org/10.1038/nrclinonc.2015.29
Secord, Angeles A., Robert L. Coleman, Laura J. Havrilesky, Amy P. Abernethy, Gregory P. Samsa, and David Cella. “Patient-reported outcomes as end points and outcome indicators in solid tumours.” Nat Rev Clin Oncol 12, no. 6 (June 2015): 358–70. https://doi.org/10.1038/nrclinonc.2015.29.
Secord AA, Coleman RL, Havrilesky LJ, Abernethy AP, Samsa GP, Cella D. Patient-reported outcomes as end points and outcome indicators in solid tumours. Nat Rev Clin Oncol. 2015 Jun;12(6):358–70.
Secord, Angeles A., et al. “Patient-reported outcomes as end points and outcome indicators in solid tumours.” Nat Rev Clin Oncol, vol. 12, no. 6, June 2015, pp. 358–70. Pubmed, doi:10.1038/nrclinonc.2015.29.
Secord AA, Coleman RL, Havrilesky LJ, Abernethy AP, Samsa GP, Cella D. Patient-reported outcomes as end points and outcome indicators in solid tumours. Nat Rev Clin Oncol. 2015 Jun;12(6):358–370.

Published In

Nat Rev Clin Oncol

DOI

10.1038/nrclinonc.2015.29

EISSN

1759-4782

Publication Date

June 2015

Volume

12

Issue

6

Start / End Page

358 / 370

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Self Report
  • Quality of Life
  • Patient-Centered Care
  • Patient Outcome Assessment
  • Neoplasms
  • Humans
  • Forecasting
  • Clinical Trials as Topic