Laura Jean Havrilesky
Professor of Obstetrics and Gynecology

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer. The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women.

Current Research Interests

I am a gynecologic oncologist with an interest in health outcomes and patient preferences. My group has performed several prospective studies of patient preferences regarding the side effects of chemotherapy, surgery, and radiation therapy treatments for ovarian and cervical cancer.  We have developed a number of health outcomes models to inform decisions related to gynecologic cancers, including screening, diagnostic testing, and treatment decisions for endometrial, cervical, and ovarian cancer. I currently serve on NRG Oncology’s Patient Centered Outcomes Research Committee and am co-chair of the Comparative Effectiveness Subcommittee for the NRG. 

Current Appointments & Affiliations

Contact Information

  • 25172 Morris Bldg, Durham, NC 27710
  • Box 3079 Med Ctr, Durham, NC 27710

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