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Neuroinflammation in Alzheimer's disease.

Publication ,  Journal Article
Heneka, MT; Carson, MJ; El Khoury, J; Landreth, GE; Brosseron, F; Feinstein, DL; Jacobs, AH; Wyss-Coray, T; Vitorica, J; Ransohoff, RM; Latz, E ...
Published in: Lancet Neurol
April 2015

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease.

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Published In

Lancet Neurol

DOI

EISSN

1474-4465

Publication Date

April 2015

Volume

14

Issue

4

Start / End Page

388 / 405

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Risk Factors
  • Protein Folding
  • Phagocytosis
  • Obesity
  • Nootropic Agents
  • Neurology & Neurosurgery
  • Microglia
  • Locus Coeruleus
  • Inflammation Mediators
 

Citation

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ICMJE
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Heneka, M. T., Carson, M. J., El Khoury, J., Landreth, G. E., Brosseron, F., Feinstein, D. L., … Kummer, M. P. (2015). Neuroinflammation in Alzheimer's disease. Lancet Neurol, 14(4), 388–405. https://doi.org/10.1016/S1474-4422(15)70016-5
Heneka, Michael T., Monica J. Carson, Joseph El Khoury, Gary E. Landreth, Frederic Brosseron, Douglas L. Feinstein, Andreas H. Jacobs, et al. “Neuroinflammation in Alzheimer's disease.Lancet Neurol 14, no. 4 (April 2015): 388–405. https://doi.org/10.1016/S1474-4422(15)70016-5.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, et al. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015 Apr;14(4):388–405.
Heneka, Michael T., et al. “Neuroinflammation in Alzheimer's disease.Lancet Neurol, vol. 14, no. 4, Apr. 2015, pp. 388–405. Pubmed, doi:10.1016/S1474-4422(15)70016-5.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015 Apr;14(4):388–405.
Journal cover image

Published In

Lancet Neurol

DOI

EISSN

1474-4465

Publication Date

April 2015

Volume

14

Issue

4

Start / End Page

388 / 405

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Risk Factors
  • Protein Folding
  • Phagocytosis
  • Obesity
  • Nootropic Agents
  • Neurology & Neurosurgery
  • Microglia
  • Locus Coeruleus
  • Inflammation Mediators