Skip to main content

Urinary F2-isoprostanes and metabolic markers of fat oxidation.

Publication ,  Journal Article
Il'yasova, D; Wagenknecht, LE; Spasojevic, I; Watkins, S; Bowden, D; Wang, F; D'Agostino, RB
Published in: Oxidative medicine and cellular longevity
January 2015

Metabolomic studies of increased fat oxidation showed increase in circulating acylcarnitines C2, C8, C10, and C12 and decrease in C3, C4, and C5. We hypothesize that urinary F2-isoprostanes reflect intensity of fatty acid oxidation and are associated with circulating C2, C8, C10, and C12 directly and with C3, C4, and C5 inversely. Four urinary F2-isoprostane isomers and serum acylcarnitines are quantified using LC-MS/MS within the Insulin Resistance Atherosclerosis Study nondiabetic cohort (n = 682). Cross-sectional associations between fasting urinary F2-isoprostanes (summarized as a composite index) and the selected acylcarnitines are examined using generalized linear models. F2-isoprostane index is associated with C2 and C12 directly and with C5 inversely: the adjusted beta coefficients are 0.109, 0.072, and -0.094, respectively (P < 0.05). For these acylcarnitines and for F2-isoprostanes, the adjusted odds ratios (ORs) of incident diabetes are calculated from logistic regression models: the ORs (95% CI) are 0.77 (0.60-0.97), 0.79 (0.62-1.01), 1.18 (0.92-1.53), and 0.51 (0.35-0.76) for C2, C12, C5, and F2-isoprostanes, respectively. The direction of the associations between urinary F2-isoprostanes and three acylcarnitines (C2, C5, and C12) supports our hypothesis. The inverse associations of C2 and C12 and with incident diabetes are consistent with the suggested protective role of efficient fat oxidation.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Oxidative medicine and cellular longevity

DOI

EISSN

1942-0994

ISSN

1942-0900

Publication Date

January 2015

Volume

2015

Start / End Page

729191

Related Subject Headings

  • Tandem Mass Spectrometry
  • Risk Factors
  • Oxidation-Reduction
  • Odds Ratio
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Female
  • Fatty Acids
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Il’yasova, D., Wagenknecht, L. E., Spasojevic, I., Watkins, S., Bowden, D., Wang, F., & D’Agostino, R. B. (2015). Urinary F2-isoprostanes and metabolic markers of fat oxidation. Oxidative Medicine and Cellular Longevity, 2015, 729191. https://doi.org/10.1155/2015/729191
Il’yasova, Dora, Lynne E. Wagenknecht, Ivan Spasojevic, Steven Watkins, Donald Bowden, Frances Wang, and Ralph B. D’Agostino. “Urinary F2-isoprostanes and metabolic markers of fat oxidation.Oxidative Medicine and Cellular Longevity 2015 (January 2015): 729191. https://doi.org/10.1155/2015/729191.
Il’yasova D, Wagenknecht LE, Spasojevic I, Watkins S, Bowden D, Wang F, et al. Urinary F2-isoprostanes and metabolic markers of fat oxidation. Oxidative medicine and cellular longevity. 2015 Jan;2015:729191.
Il’yasova, Dora, et al. “Urinary F2-isoprostanes and metabolic markers of fat oxidation.Oxidative Medicine and Cellular Longevity, vol. 2015, Jan. 2015, p. 729191. Epmc, doi:10.1155/2015/729191.
Il’yasova D, Wagenknecht LE, Spasojevic I, Watkins S, Bowden D, Wang F, D’Agostino RB. Urinary F2-isoprostanes and metabolic markers of fat oxidation. Oxidative medicine and cellular longevity. 2015 Jan;2015:729191.

Published In

Oxidative medicine and cellular longevity

DOI

EISSN

1942-0994

ISSN

1942-0900

Publication Date

January 2015

Volume

2015

Start / End Page

729191

Related Subject Headings

  • Tandem Mass Spectrometry
  • Risk Factors
  • Oxidation-Reduction
  • Odds Ratio
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Female
  • Fatty Acids