Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
Publication
, Journal Article
Lamoth, F; Alexander, BD
Published in: Antimicrob Agents Chemother
July 2015
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
July 2015
Volume
59
Issue
7
Start / End Page
4308 / 4311
Location
United States
Related Subject Headings
- Triterpenes
- Retrospective Studies
- Mycoses
- Microbiology
- Microbial Sensitivity Tests
- Humans
- Glycosides
- Glucosyltransferases
- Fungi
- Echinocandins
Citation
APA
Chicago
ICMJE
MLA
NLM
Lamoth, F., & Alexander, B. D. (2015). Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates. Antimicrob Agents Chemother, 59(7), 4308–4311. https://doi.org/10.1128/AAC.00234-15
Lamoth, Frédéric, and Barbara D. Alexander. “Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.” Antimicrob Agents Chemother 59, no. 7 (July 2015): 4308–11. https://doi.org/10.1128/AAC.00234-15.
Lamoth F, Alexander BD. Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates. Antimicrob Agents Chemother. 2015 Jul;59(7):4308–11.
Lamoth, Frédéric, and Barbara D. Alexander. “Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.” Antimicrob Agents Chemother, vol. 59, no. 7, July 2015, pp. 4308–11. Pubmed, doi:10.1128/AAC.00234-15.
Lamoth F, Alexander BD. Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates. Antimicrob Agents Chemother. 2015 Jul;59(7):4308–4311.
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
July 2015
Volume
59
Issue
7
Start / End Page
4308 / 4311
Location
United States
Related Subject Headings
- Triterpenes
- Retrospective Studies
- Mycoses
- Microbiology
- Microbial Sensitivity Tests
- Humans
- Glycosides
- Glucosyltransferases
- Fungi
- Echinocandins