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Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid.

Publication ,  Journal Article
Liu, X-C; Holtze, M; Powell, SB; Terrando, N; Larsson, MK; Persson, A; Olsson, SK; Orhan, F; Kegel, M; Asp, L; Goiny, M; Schwieler, L ...
Published in: Brain Behav Immun
February 2014

Exposure to infections in early life is considered a risk-factor for developing schizophrenia. Recently we reported that a neonatal CNS infection with influenza A virus in mice resulted in a transient induction of the brain kynurenine pathway, and subsequent behavioral disturbances in immune-deficient adult mice. The aim of the present study was to investigate a potential role in this regard of kynurenic acid (KYNA), an endogenous antagonist at the glycine site of the N-methyl-D-aspartic acid (NMDA) receptor and at the cholinergic α7 nicotinic receptor. C57BL/6 mice were injected i.p. with neurotropic influenza A/WSN/33 virus (2400 plaque-forming units) at postnatal day (P) 3 or with L-kynurenine (2×200 mg/kg/day) at P7-16. In mice neonatally treated with L-kynurenine prepulse inhibition of the acoustic startle, anxiety, and learning and memory were also assessed. Neonatally infected mice showed enhanced sensitivity to D-amphetamine-induced (5 mg/kg i.p.) increase in locomotor activity as adults. Neonatally L-kynurenine treated mice showed enhanced sensitivity to D-amphetamine-induced (5 mg/kg i.p.) increase in locomotor activity as well as mild impairments in prepulse inhibition and memory. Also, D-amphetamine tended to potentiate dopamine release in the striatum in kynurenine-treated mice. These long-lasting behavioral and neurochemical alterations suggest that the kynurenine pathway can link early-life infection with the development of neuropsychiatric disturbances in adulthood.

Duke Scholars

Published In

Brain Behav Immun

DOI

EISSN

1090-2139

Publication Date

February 2014

Volume

36

Start / End Page

80 / 89

Location

Netherlands

Related Subject Headings

  • Orthomyxoviridae Infections
  • Neurology & Neurosurgery
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Kynurenine
  • Kynurenic Acid
  • Influenza A virus
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, X.-C., Holtze, M., Powell, S. B., Terrando, N., Larsson, M. K., Persson, A., … Erhardt, S. (2014). Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. Brain Behav Immun, 36, 80–89. https://doi.org/10.1016/j.bbi.2013.10.010
Liu, Xi-Cong, Maria Holtze, Susan B. Powell, Niccolò Terrando, Markus K. Larsson, Anna Persson, Sara K. Olsson, et al. “Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid.Brain Behav Immun 36 (February 2014): 80–89. https://doi.org/10.1016/j.bbi.2013.10.010.
Liu X-C, Holtze M, Powell SB, Terrando N, Larsson MK, Persson A, et al. Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. Brain Behav Immun. 2014 Feb;36:80–9.
Liu, Xi-Cong, et al. “Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid.Brain Behav Immun, vol. 36, Feb. 2014, pp. 80–89. Pubmed, doi:10.1016/j.bbi.2013.10.010.
Liu X-C, Holtze M, Powell SB, Terrando N, Larsson MK, Persson A, Olsson SK, Orhan F, Kegel M, Asp L, Goiny M, Schwieler L, Engberg G, Karlsson H, Erhardt S. Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. Brain Behav Immun. 2014 Feb;36:80–89.
Journal cover image

Published In

Brain Behav Immun

DOI

EISSN

1090-2139

Publication Date

February 2014

Volume

36

Start / End Page

80 / 89

Location

Netherlands

Related Subject Headings

  • Orthomyxoviridae Infections
  • Neurology & Neurosurgery
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Kynurenine
  • Kynurenic Acid
  • Influenza A virus
  • Female