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The lung is protected from spontaneous inflammation by autophagy in myeloid cells.

Publication ,  Journal Article
Kanayama, M; He, Y-W; Shinohara, ML
Published in: J Immunol
June 1, 2015

The lung is constantly exposed to the outer environment; thus, it must maintain a state of immune ignorance or tolerance not to overrespond to harmless environmental stimuli. How cells in the lung control immune responses under nonpathogenic condition is not fully understood. In this study, we found that autophagy plays a critical role in the lung-specific immune regulation that prevents spontaneous inflammation. Autophagy in pulmonary myeloid cells plays a role in maintaining low burdens of environmental microbes in the lung, as well as in lowering mitochondrial reactive oxygen species production and preventing overresponse to TLR4 ligands in alveolar macrophages. Based on these mechanisms, we also found that intranasal instillation of antibiotics or an inhibitor of reactive oxygen species was efficient in preventing spontaneous pulmonary inflammation. Thus, autophagy in myeloid cells, particularly alveolar macrophages, is critical for inhibiting spontaneous pulmonary inflammation, and pulmonary inflammation caused by dysfunctional autophagy is pharmacologically prevented.

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Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

June 1, 2015

Volume

194

Issue

11

Start / End Page

5465 / 5471

Location

United States

Related Subject Headings

  • Toll-Like Receptor 4
  • Reactive Oxygen Species
  • Pneumonia
  • Myeloid Cells
  • Mitochondria
  • Microtubule-Associated Proteins
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Macrophages, Alveolar
 

Citation

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Kanayama, M., He, Y.-W., & Shinohara, M. L. (2015). The lung is protected from spontaneous inflammation by autophagy in myeloid cells. J Immunol, 194(11), 5465–5471. https://doi.org/10.4049/jimmunol.1403249
Kanayama, Masashi, You-Wen He, and Mari L. Shinohara. “The lung is protected from spontaneous inflammation by autophagy in myeloid cells.J Immunol 194, no. 11 (June 1, 2015): 5465–71. https://doi.org/10.4049/jimmunol.1403249.
Kanayama M, He Y-W, Shinohara ML. The lung is protected from spontaneous inflammation by autophagy in myeloid cells. J Immunol. 2015 Jun 1;194(11):5465–71.
Kanayama, Masashi, et al. “The lung is protected from spontaneous inflammation by autophagy in myeloid cells.J Immunol, vol. 194, no. 11, June 2015, pp. 5465–71. Pubmed, doi:10.4049/jimmunol.1403249.
Kanayama M, He Y-W, Shinohara ML. The lung is protected from spontaneous inflammation by autophagy in myeloid cells. J Immunol. 2015 Jun 1;194(11):5465–5471.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

June 1, 2015

Volume

194

Issue

11

Start / End Page

5465 / 5471

Location

United States

Related Subject Headings

  • Toll-Like Receptor 4
  • Reactive Oxygen Species
  • Pneumonia
  • Myeloid Cells
  • Mitochondria
  • Microtubule-Associated Proteins
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Macrophages, Alveolar