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Tissue-engineered blood vessels as promising tools for testing drug toxicity.

Publication ,  Journal Article
Truskey, GA; Fernandez, CE
Published in: Expert opinion on drug metabolism & toxicology
July 2015

Drug-induced vascular injury (DIVI) is a serious problem in preclinical studies of vasoactive molecules and for survivors of pediatric cancers. DIVI is often observed in rodents and some larger animals, primarily with drugs affecting vascular tone, but not in humans; however, DIVI observed in animal studies often precludes a drug candidate from continuing along the development pipeline. Thus, there is great interest by the pharmaceutical industry to identify quantifiable human biomarkers of DIVI. Small-scale endothelialized tissue-engineered blood vessels using human cells represent a promising approach to screen drug candidates and develop alternatives to cancer therapeutics in vitro. We identify several technical challenges that remain to be addressed, including high-throughput systems to screen large numbers of candidates, identification of suitable cell sources and establishing and maintaining a differentiated state of the vessel wall cells. Adequately addressing these challenges should yield novel platforms to screen drugs and develop new therapeutics to treat cardiovascular disease.

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Published In

Expert opinion on drug metabolism & toxicology

DOI

EISSN

1744-7607

ISSN

1742-5255

Publication Date

July 2015

Volume

11

Issue

7

Start / End Page

1021 / 1024

Related Subject Headings

  • Vascular Diseases
  • Toxicity Tests
  • Tissue Engineering
  • Species Specificity
  • Pharmacology & Pharmacy
  • Humans
  • High-Throughput Screening Assays
  • Drug Evaluation, Preclinical
  • Drug Design
  • Blood Vessels
 

Citation

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Truskey, G. A., & Fernandez, C. E. (2015). Tissue-engineered blood vessels as promising tools for testing drug toxicity. Expert Opinion on Drug Metabolism & Toxicology, 11(7), 1021–1024. https://doi.org/10.1517/17425255.2015.1047342
Truskey, George A., and Cristina E. Fernandez. “Tissue-engineered blood vessels as promising tools for testing drug toxicity.Expert Opinion on Drug Metabolism & Toxicology 11, no. 7 (July 2015): 1021–24. https://doi.org/10.1517/17425255.2015.1047342.
Truskey GA, Fernandez CE. Tissue-engineered blood vessels as promising tools for testing drug toxicity. Expert opinion on drug metabolism & toxicology. 2015 Jul;11(7):1021–4.
Truskey, George A., and Cristina E. Fernandez. “Tissue-engineered blood vessels as promising tools for testing drug toxicity.Expert Opinion on Drug Metabolism & Toxicology, vol. 11, no. 7, July 2015, pp. 1021–24. Epmc, doi:10.1517/17425255.2015.1047342.
Truskey GA, Fernandez CE. Tissue-engineered blood vessels as promising tools for testing drug toxicity. Expert opinion on drug metabolism & toxicology. 2015 Jul;11(7):1021–1024.

Published In

Expert opinion on drug metabolism & toxicology

DOI

EISSN

1744-7607

ISSN

1742-5255

Publication Date

July 2015

Volume

11

Issue

7

Start / End Page

1021 / 1024

Related Subject Headings

  • Vascular Diseases
  • Toxicity Tests
  • Tissue Engineering
  • Species Specificity
  • Pharmacology & Pharmacy
  • Humans
  • High-Throughput Screening Assays
  • Drug Evaluation, Preclinical
  • Drug Design
  • Blood Vessels