A niche role for cancer exosomes in metastasis.
Publication
, Journal Article
Zhang, Y; Wang, X-F
Published in: Nat Cell Biol
June 2015
Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic niche formation through a multi-step process. This involves uptake of exosome-derived factors by liver Kupffer cells and hepatic stellate cell activation to generate a fibrotic microenvironment with immune cell infiltrates that favours metastasis.
Duke Scholars
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Published In
Nat Cell Biol
DOI
EISSN
1476-4679
Publication Date
June 2015
Volume
17
Issue
6
Start / End Page
709 / 711
Location
England
Related Subject Headings
- Pancreatic Neoplasms
- Macrophage Migration-Inhibitory Factors
- Liver Neoplasms
- Humans
- Female
- Exosomes
- Developmental Biology
- Carcinoma, Pancreatic Ductal
- Animals
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, Y., & Wang, X.-F. (2015). A niche role for cancer exosomes in metastasis. Nat Cell Biol, 17(6), 709–711. https://doi.org/10.1038/ncb3181
Zhang, Yun, and Xiao-Fan Wang. “A niche role for cancer exosomes in metastasis.” Nat Cell Biol 17, no. 6 (June 2015): 709–11. https://doi.org/10.1038/ncb3181.
Zhang Y, Wang X-F. A niche role for cancer exosomes in metastasis. Nat Cell Biol. 2015 Jun;17(6):709–11.
Zhang, Yun, and Xiao-Fan Wang. “A niche role for cancer exosomes in metastasis.” Nat Cell Biol, vol. 17, no. 6, June 2015, pp. 709–11. Pubmed, doi:10.1038/ncb3181.
Zhang Y, Wang X-F. A niche role for cancer exosomes in metastasis. Nat Cell Biol. 2015 Jun;17(6):709–711.
Published In
Nat Cell Biol
DOI
EISSN
1476-4679
Publication Date
June 2015
Volume
17
Issue
6
Start / End Page
709 / 711
Location
England
Related Subject Headings
- Pancreatic Neoplasms
- Macrophage Migration-Inhibitory Factors
- Liver Neoplasms
- Humans
- Female
- Exosomes
- Developmental Biology
- Carcinoma, Pancreatic Ductal
- Animals
- 3101 Biochemistry and cell biology