Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel
Journal cover image

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons.

Publication ,  Journal Article
Meng, L; Mulcahy, B; Cook, SJ; Neubauer, M; Wan, A; Jin, Y; Yan, D
Published in: Cell Rep
June 23, 2015

Synapse elimination occurs in development, plasticity, and disease. Although the importance of synapse elimination has been documented in many studies, the molecular mechanisms underlying this process are unclear. Here, using the development of C. elegans RME neurons as a model, we have uncovered a function for the apoptosis pathway in synapse elimination. We find that the conserved apoptotic cell death (CED) pathway and axonal mitochondria are required for the elimination of transiently formed clusters of presynaptic components in RME neurons. This function of the CED pathway involves the activation of the actin-filament-severing protein, GSNL-1. Furthermore, we show that caspase CED-3 cleaves GSNL-1 at a conserved C-terminal region and that the cleaved active form of GSNL-1 promotes its actin-severing ability. Our data suggest that activation of the CED pathway contributes to selective elimination of synapses through disassembly of the actin filament network.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

June 23, 2015

Volume

11

Issue

11

Start / End Page

1737 / 1748

Location

United States

Related Subject Headings

  • Synapses
  • Proteolysis
  • Neurons
  • Molecular Sequence Data
  • Mitochondria
  • Intracellular Calcium-Sensing Proteins
  • Caspases
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Apoptosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Meng, L., Mulcahy, B., Cook, S. J., Neubauer, M., Wan, A., Jin, Y., & Yan, D. (2015). The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons. Cell Rep, 11(11), 1737–1748. https://doi.org/10.1016/j.celrep.2015.05.031
Meng, Lingfeng, Ben Mulcahy, Steven J. Cook, Marianna Neubauer, Airong Wan, Yishi Jin, and Dong Yan. “The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons.Cell Rep 11, no. 11 (June 23, 2015): 1737–48. https://doi.org/10.1016/j.celrep.2015.05.031.
Meng L, Mulcahy B, Cook SJ, Neubauer M, Wan A, Jin Y, et al. The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons. Cell Rep. 2015 Jun 23;11(11):1737–48.
Meng, Lingfeng, et al. “The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons.Cell Rep, vol. 11, no. 11, June 2015, pp. 1737–48. Pubmed, doi:10.1016/j.celrep.2015.05.031.
Meng L, Mulcahy B, Cook SJ, Neubauer M, Wan A, Jin Y, Yan D. The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons. Cell Rep. 2015 Jun 23;11(11):1737–1748.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

June 23, 2015

Volume

11

Issue

11

Start / End Page

1737 / 1748

Location

United States

Related Subject Headings

  • Synapses
  • Proteolysis
  • Neurons
  • Molecular Sequence Data
  • Mitochondria
  • Intracellular Calcium-Sensing Proteins
  • Caspases
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Apoptosis