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Human brain diffusion tensor imaging at submillimeter isotropic resolution on a 3Tesla clinical MRI scanner.
The advantages of high-resolution diffusion tensor imaging (DTI) have been demonstrated in a recent post-mortem human brain study (Miller et al., NeuroImage 2011;57(1):167-181), showing that white matter fiber tracts can be much more accurately detected in data at a submillimeter isotropic resolution. To our knowledge, in vivo human brain DTI at a submillimeter isotropic resolution has not been routinely achieved yet because of the difficulty in simultaneously achieving high resolution and high signal-to-noise ratio (SNR) in DTI scans. Here we report a 3D multi-slab interleaved EPI acquisition integrated with multiplexed sensitivity encoded (MUSE) reconstruction, to achieve high-quality, high-SNR and submillimeter isotropic resolution (0.85×0.85×0.85mm(3)) in vivo human brain DTI on a 3Tesla clinical MRI scanner. In agreement with the previously reported post-mortem human brain DTI study, our in vivo data show that the structural connectivity networks of human brains can be mapped more accurately and completely with high-resolution DTI as compared with conventional DTI (e.g., 2×2×2mm(3)).
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Related Subject Headings
- Neurology & Neurosurgery
- Neural Pathways
- Imaging, Three-Dimensional
- Image Processing, Computer-Assisted
- Humans
- Diffusion Magnetic Resonance Imaging
- Brain Mapping
- Brain
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=1095-9572&client=dukeuniv)
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Neurology & Neurosurgery
- Neural Pathways
- Imaging, Three-Dimensional
- Image Processing, Computer-Assisted
- Humans
- Diffusion Magnetic Resonance Imaging
- Brain Mapping
- Brain
- 42 Health sciences
- 32 Biomedical and clinical sciences