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The role of hedgehog signalling in skeletal health and disease.

Publication ,  Journal Article
Alman, BA
Published in: Nat Rev Rheumatol
September 2015

Hedgehog ligands bind to protein patched homologue 1 (PTC), a conserved receptor that activates the GLI family of transcription factors, which are involved in development, disease and skeletal repair processes. During embryonic development, hedgehog signalling helps to pattern the limbs and plays a critical part in regulating chondrocyte differentiation and osteogenesis during the longitudinal growth of long bones. This signalling pathway also regulates mesenchymal cell differentiation during skeletal repair and regeneration. In pathologic and degenerative processes, such as osteoarthritis or cartilaginous tumour formation, hedgehog signalling is dysregulated. Several pharmacologic strategies can modulate hedgehog signalling, and targeting this pathway could lead to the development of novel therapeutic approaches. For example, by precisely regulating the level of activity of the hedgehog signalling pathway, the pace of degeneration in osteoarthritis could be slowed, bone repair could be enhanced, and cartilaginous tumour cell viability could be inhibited. As such, regulation of hedgehog signalling could be manipulated to safeguard skeletal health.

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Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

September 2015

Volume

11

Issue

9

Start / End Page

552 / 560

Location

United States

Related Subject Headings

  • Signal Transduction
  • Humans
  • Hedgehog Proteins
  • Bone and Bones
  • Bone Diseases
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Alman, B. A. (2015). The role of hedgehog signalling in skeletal health and disease. Nat Rev Rheumatol, 11(9), 552–560. https://doi.org/10.1038/nrrheum.2015.84
Alman, Benjamin A. “The role of hedgehog signalling in skeletal health and disease.Nat Rev Rheumatol 11, no. 9 (September 2015): 552–60. https://doi.org/10.1038/nrrheum.2015.84.
Alman BA. The role of hedgehog signalling in skeletal health and disease. Nat Rev Rheumatol. 2015 Sep;11(9):552–60.
Alman, Benjamin A. “The role of hedgehog signalling in skeletal health and disease.Nat Rev Rheumatol, vol. 11, no. 9, Sept. 2015, pp. 552–60. Pubmed, doi:10.1038/nrrheum.2015.84.
Alman BA. The role of hedgehog signalling in skeletal health and disease. Nat Rev Rheumatol. 2015 Sep;11(9):552–560.

Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

September 2015

Volume

11

Issue

9

Start / End Page

552 / 560

Location

United States

Related Subject Headings

  • Signal Transduction
  • Humans
  • Hedgehog Proteins
  • Bone and Bones
  • Bone Diseases
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences