Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.
Publication
, Journal Article
Maher, JR; Chuchuen, O; Henderson, MH; Kim, S; Rinehart, MT; Kashuba, ADM; Wax, A; Katz, DF
Published in: Biomedical optics express
June 2015
We report the development of a combined confocal Raman spectroscopy (CRS) and optical coherence tomography (OCT) instrument (CRS-OCT) capable of measuring analytes in targeted biological tissues with sub-100-micron spatial resolution. The OCT subsystem was used to measure depth-resolved tissue morphology and guide the acquisition of chemically-specific Raman spectra. To demonstrate its utility, the instrument was used to accurately measure depth-resolved, physiologically-relevant concentrations of Tenofovir, a microbicide drug used to prevent the sexual transmission of HIV, in ex vivo tissue samples.
Duke Scholars
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Published In
Biomedical optics express
DOI
EISSN
2156-7085
ISSN
2156-7085
Publication Date
June 2015
Volume
6
Issue
6
Start / End Page
2022 / 2035
Related Subject Headings
- 5102 Atomic, molecular and optical physics
- 4003 Biomedical engineering
- 3212 Ophthalmology and optometry
- 0912 Materials Engineering
- 0205 Optical Physics
Citation
APA
Chicago
ICMJE
MLA
NLM
Maher, J. R., Chuchuen, O., Henderson, M. H., Kim, S., Rinehart, M. T., Kashuba, A. D. M., … Katz, D. F. (2015). Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue. Biomedical Optics Express, 6(6), 2022–2035. https://doi.org/10.1364/boe.6.002022
Maher, Jason R., Oranat Chuchuen, Marcus H. Henderson, Sanghoon Kim, Matthew T. Rinehart, Angela D. M. Kashuba, Adam Wax, and David F. Katz. “Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.” Biomedical Optics Express 6, no. 6 (June 2015): 2022–35. https://doi.org/10.1364/boe.6.002022.
Maher JR, Chuchuen O, Henderson MH, Kim S, Rinehart MT, Kashuba ADM, et al. Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue. Biomedical optics express. 2015 Jun;6(6):2022–35.
Maher, Jason R., et al. “Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.” Biomedical Optics Express, vol. 6, no. 6, June 2015, pp. 2022–35. Epmc, doi:10.1364/boe.6.002022.
Maher JR, Chuchuen O, Henderson MH, Kim S, Rinehart MT, Kashuba ADM, Wax A, Katz DF. Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue. Biomedical optics express. 2015 Jun;6(6):2022–2035.
Published In
Biomedical optics express
DOI
EISSN
2156-7085
ISSN
2156-7085
Publication Date
June 2015
Volume
6
Issue
6
Start / End Page
2022 / 2035
Related Subject Headings
- 5102 Atomic, molecular and optical physics
- 4003 Biomedical engineering
- 3212 Ophthalmology and optometry
- 0912 Materials Engineering
- 0205 Optical Physics