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Determination of contrast media administration to achieve a targeted contrast enhancement in CT

Publication ,  Conference
Sahbaee, P; Li, Y; Segars, P; Marin, D; Nelson, R; Samei, E
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
January 1, 2015

Contrast enhancement is a key component of CT imaging and offer opportunities for optimization. The design and optimization of new techniques however requires orchestration with the scan parameters and further a methodology to relate contrast enhancement and injection function. In this study, we used such a methodology to develop a method, analytical inverse method, to predict the required injection function to achieve a desired contrast enhancement in a given organ by incorporation of a physiologically based compartmental model. The method was evaluated across 32 different target contrast enhancement functions for aorta, kidney, stomach, small intestine, and liver. The results exhibited that the analytical inverse method offers accurate performance with error in the range of 10% deviation between the predicted and desired organ enhancement curves. However, this method is incapable of predicting the injection function based on the liver enhancement. The findings of this study can be useful in optimizing contrast medium injection function as well as the scan timing to provide more consistency in the way that the contrast enhanced CT examinations are performed. To our knowledge, this work is one of the first attempts to predict the contrast material injection function for a desired organ enhancement curve.

Duke Scholars

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

ISBN

9781628415025

Publication Date

January 1, 2015

Volume

9412
 

Citation

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Sahbaee, P., Li, Y., Segars, P., Marin, D., Nelson, R., & Samei, E. (2015). Determination of contrast media administration to achieve a targeted contrast enhancement in CT. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9412). https://doi.org/10.1117/12.2082261
Sahbaee, P., Y. Li, P. Segars, D. Marin, R. Nelson, and E. Samei. “Determination of contrast media administration to achieve a targeted contrast enhancement in CT.” In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 9412, 2015. https://doi.org/10.1117/12.2082261.
Sahbaee P, Li Y, Segars P, Marin D, Nelson R, Samei E. Determination of contrast media administration to achieve a targeted contrast enhancement in CT. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2015.
Sahbaee, P., et al. “Determination of contrast media administration to achieve a targeted contrast enhancement in CT.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9412, 2015. Scopus, doi:10.1117/12.2082261.
Sahbaee P, Li Y, Segars P, Marin D, Nelson R, Samei E. Determination of contrast media administration to achieve a targeted contrast enhancement in CT. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2015.
Journal cover image

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

ISBN

9781628415025

Publication Date

January 1, 2015

Volume

9412