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In vivo penetration mechanics and mechanical properties of mouse brain tissue at micrometer scales.

Publication ,  Journal Article
Sharp, AA; Ortega, AM; Restrepo, D; Curran-Everett, D; Gall, K
Published in: IEEE transactions on bio-medical engineering
January 2009

Substantial advancement in the understanding of the neuronal basis of behavior and the treatment of neurological disorders has been achieved via the implantation of various devices into the brain. To design and optimize the next generation of neuronal implants while striving to minimize tissue damage, it is necessary to understand the mechanics of probe insertion at relevant length scales. Unfortunately, a broad-based understanding of brain-implant interactions at the necessary micrometer scales is largely missing. This paper presents a generalizable description of the micrometer-scale penetration mechanics and material properties of mouse brain tissue in vivo. Cylindrical stainless steel probes were inserted into the cerebral cortex and olfactory bulb of mice. The effects of probe size, probe geometry, insertion rate, insertion location, animal age, and the presence of the dura and pia on the resulting forces were measured continuously throughout probe insertion and removal. Material properties (modulus, cutting force, and frictional force) were extracted using mechanical analysis. The use of rigid, incompressible, cylindrical probes allows for a general understanding of how probe design and insertion methods influence the penetration mechanics of brain tissue in vivo that can be applied to the quantitative design of most future implantable devices.

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Published In

IEEE transactions on bio-medical engineering

DOI

EISSN

1558-2531

ISSN

0018-9294

Publication Date

January 2009

Volume

56

Issue

1

Start / End Page

45 / 53

Related Subject Headings

  • Stress, Mechanical
  • Stainless Steel
  • Prostheses and Implants
  • Poisson Distribution
  • Pia Mater
  • Olfactory Bulb
  • Microscopy, Electron, Scanning
  • Mice
  • Elastic Modulus
  • Dura Mater
 

Citation

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Sharp, A. A., Ortega, A. M., Restrepo, D., Curran-Everett, D., & Gall, K. (2009). In vivo penetration mechanics and mechanical properties of mouse brain tissue at micrometer scales. IEEE Transactions on Bio-Medical Engineering, 56(1), 45–53. https://doi.org/10.1109/tbme.2008.2003261
Sharp, Andrew A., Alicia M. Ortega, Diego Restrepo, Douglas Curran-Everett, and Ken Gall. “In vivo penetration mechanics and mechanical properties of mouse brain tissue at micrometer scales.IEEE Transactions on Bio-Medical Engineering 56, no. 1 (January 2009): 45–53. https://doi.org/10.1109/tbme.2008.2003261.
Sharp AA, Ortega AM, Restrepo D, Curran-Everett D, Gall K. In vivo penetration mechanics and mechanical properties of mouse brain tissue at micrometer scales. IEEE transactions on bio-medical engineering. 2009 Jan;56(1):45–53.
Sharp, Andrew A., et al. “In vivo penetration mechanics and mechanical properties of mouse brain tissue at micrometer scales.IEEE Transactions on Bio-Medical Engineering, vol. 56, no. 1, Jan. 2009, pp. 45–53. Epmc, doi:10.1109/tbme.2008.2003261.
Sharp AA, Ortega AM, Restrepo D, Curran-Everett D, Gall K. In vivo penetration mechanics and mechanical properties of mouse brain tissue at micrometer scales. IEEE transactions on bio-medical engineering. 2009 Jan;56(1):45–53.

Published In

IEEE transactions on bio-medical engineering

DOI

EISSN

1558-2531

ISSN

0018-9294

Publication Date

January 2009

Volume

56

Issue

1

Start / End Page

45 / 53

Related Subject Headings

  • Stress, Mechanical
  • Stainless Steel
  • Prostheses and Implants
  • Poisson Distribution
  • Pia Mater
  • Olfactory Bulb
  • Microscopy, Electron, Scanning
  • Mice
  • Elastic Modulus
  • Dura Mater