Skip to main content
Journal cover image

High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants.

Publication ,  Journal Article
Evans, NT; Torstrick, FB; Lee, CSD; Dupont, KM; Safranski, DL; Chang, WA; Macedo, AE; Lin, ASP; Boothby, JM; Whittingslow, DC; Carson, RA ...
Published in: Acta biomaterialia
February 2015

Despite its widespread clinical use in load-bearing orthopedic implants, polyether-ether-ketone (PEEK) is often associated with poor osseointegration. In this study, a surface-porous PEEK material (PEEK-SP) was created using a melt extrusion technique. The porous layer was 399.6±63.3 μm thick and possessed a mean pore size of 279.9±31.6 μm, strut spacing of 186.8±55.5 μm, porosity of 67.3±3.1% and interconnectivity of 99.9±0.1%. Monotonic tensile tests showed that PEEK-SP preserved 73.9% of the strength (71.06±2.17 MPa) and 73.4% of the elastic modulus (2.45±0.31 GPa) of as-received, injection-molded PEEK. PEEK-SP further demonstrated a fatigue strength of 60.0 MPa at one million cycles, preserving 73.4% of the fatigue resistance of injection-molded PEEK. Interfacial shear testing showed the pore layer shear strength to be 23.96±2.26 MPa. An osseointegration model in the rat revealed substantial bone formation within the pore layer at 6 and 12 weeks via microcomputed tomography and histological evaluation. Ingrown bone was more closely apposed to the pore wall and fibrous tissue growth was reduced in PEEK-SP when compared to non-porous PEEK controls. These results indicate that PEEK-SP could provide improved osseointegration while maintaining the structural integrity necessary for load-bearing orthopedic applications.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Acta biomaterialia

DOI

EISSN

1878-7568

ISSN

1742-7061

Publication Date

February 2015

Volume

13

Start / End Page

159 / 167

Related Subject Headings

  • Weight-Bearing
  • Rats, Sprague-Dawley
  • Rats
  • Polymers
  • Polyethylene Glycols
  • Osseointegration
  • Orthopedic Procedures
  • Ketones
  • Femur
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Evans, N. T., Torstrick, F. B., Lee, C. S. D., Dupont, K. M., Safranski, D. L., Chang, W. A., … Gall, K. (2015). High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants. Acta Biomaterialia, 13, 159–167. https://doi.org/10.1016/j.actbio.2014.11.030
Evans, Nathan T., F Brennan Torstrick, Christopher S. D. Lee, Kenneth M. Dupont, David L. Safranski, W Allen Chang, Annie E. Macedo, et al. “High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants.Acta Biomaterialia 13 (February 2015): 159–67. https://doi.org/10.1016/j.actbio.2014.11.030.
Evans NT, Torstrick FB, Lee CSD, Dupont KM, Safranski DL, Chang WA, et al. High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants. Acta biomaterialia. 2015 Feb;13:159–67.
Evans, Nathan T., et al. “High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants.Acta Biomaterialia, vol. 13, Feb. 2015, pp. 159–67. Epmc, doi:10.1016/j.actbio.2014.11.030.
Evans NT, Torstrick FB, Lee CSD, Dupont KM, Safranski DL, Chang WA, Macedo AE, Lin ASP, Boothby JM, Whittingslow DC, Carson RA, Guldberg RE, Gall K. High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants. Acta biomaterialia. 2015 Feb;13:159–167.
Journal cover image

Published In

Acta biomaterialia

DOI

EISSN

1878-7568

ISSN

1742-7061

Publication Date

February 2015

Volume

13

Start / End Page

159 / 167

Related Subject Headings

  • Weight-Bearing
  • Rats, Sprague-Dawley
  • Rats
  • Polymers
  • Polyethylene Glycols
  • Osseointegration
  • Orthopedic Procedures
  • Ketones
  • Femur
  • Female