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Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks.

Publication ,  Journal Article
Safranski, DL; Weiss, D; Clark, JB; Caspersen, BS; Taylor, WR; Gall, K
Published in: Journal of biomedical materials research. Part A
February 2011

Poly(β-amino ester) networks have shown promise as tissue scaffolds. The objective of this work was to examine the effect of changing poly(ethylene glycol) diacrylate concentration on poly(β-amino ester) network properties and to assess the degradable polymers' in vivo response, using magnetic resonance imaging (MRI) and immunohistochemistry. The networks were synthesized from hexanediol diacrylate (HDDA), poly(ethylene glycol) diacrylate (PEGDA), and a primary amine, 3-methoxypropylamine (3-MOPA), with a fixed overall molar ratio of diacrylate to amine. Network properties were verified to insure that the networks possessed equivalent initial properties and structure other than chemistry. The effect of varying PEGDA concentration on water content, mass loss, and modulus was determined, where increasing the concentration of PEGDA increases both water content, mass loss rate, and decreases modulus. We also show that manipulating the network composition at ratios of 0:100, 10:90 and 25:75 (PEGDA:HDDA) does not elicit a major inflammatory response to subcutaneous implantation of the networks in mice. This work provides a foundation for tailoring poly(β-amino ester) networks, based on degradation rate and modulus, as a means to tune the polymer properties for various biomedical applications.

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Published In

Journal of biomedical materials research. Part A

DOI

EISSN

1552-4965

ISSN

1549-3296

Publication Date

February 2011

Volume

96

Issue

2

Start / End Page

320 / 329

Related Subject Headings

  • Water
  • Tissue Scaffolds
  • Time Factors
  • Spectroscopy, Fourier Transform Infrared
  • Skin
  • Prosthesis Implantation
  • Polymers
  • Polymerization
  • Polyethylene Glycols
  • Mice
 

Citation

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Safranski, D. L., Weiss, D., Clark, J. B., Caspersen, B. S., Taylor, W. R., & Gall, K. (2011). Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks. Journal of Biomedical Materials Research. Part A, 96(2), 320–329. https://doi.org/10.1002/jbm.a.32983
Safranski, David L., Daiana Weiss, J Brian Clark, Birgitta S. Caspersen, W Robert Taylor, and Ken Gall. “Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks.Journal of Biomedical Materials Research. Part A 96, no. 2 (February 2011): 320–29. https://doi.org/10.1002/jbm.a.32983.
Safranski DL, Weiss D, Clark JB, Caspersen BS, Taylor WR, Gall K. Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks. Journal of biomedical materials research Part A. 2011 Feb;96(2):320–9.
Safranski, David L., et al. “Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks.Journal of Biomedical Materials Research. Part A, vol. 96, no. 2, Feb. 2011, pp. 320–29. Epmc, doi:10.1002/jbm.a.32983.
Safranski DL, Weiss D, Clark JB, Caspersen BS, Taylor WR, Gall K. Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks. Journal of biomedical materials research Part A. 2011 Feb;96(2):320–329.
Journal cover image

Published In

Journal of biomedical materials research. Part A

DOI

EISSN

1552-4965

ISSN

1549-3296

Publication Date

February 2011

Volume

96

Issue

2

Start / End Page

320 / 329

Related Subject Headings

  • Water
  • Tissue Scaffolds
  • Time Factors
  • Spectroscopy, Fourier Transform Infrared
  • Skin
  • Prosthesis Implantation
  • Polymers
  • Polymerization
  • Polyethylene Glycols
  • Mice