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The effect of chemistry on the polymerization, thermo-mechanical properties and degradation rate of poly(β-amino ester) networks

Publication ,  Journal Article
Safranski, DL; Lesniewski, MA; Caspersen, BS; Uriarte, VM; Gall, K
Published in: Polymer
January 1, 2010

Poly(β-amino ester) networks are gaining attention as a scaffold material for tissue engineering applications where it is important to have tailorable degradation rate and elastic modulus. The objective of this work is to characterize and understand the relationships between chemical structure, polymerization, thermo-mechanical properties, and degradation in poly(β-amino esters) networks. The networks were synthesized from a primary amine with systematically varied molar ratios and chemical structures of diacrylates. Fundamental trends were established between the chemical structure, conversion during polymerization, macromer molecular weight, rubbery modulus, and degradation rate. The thermo-mechanical properties were dependent upon both polymerization steps. The rubbery modulus was tailorable over a range of several MPa by changing molar ratio and diacrylate molecular weight. The degradation rate ranged from hours to months depending upon the composition. Select chemical structures showed degradation rate independent of modulus. This work provides a basis for designing poly(β-amino esters) networks with specific thermo-mechanical properties and degradation rates for biomedical scaffolds. © 2010 Elsevier Ltd.

Duke Scholars

Published In

Polymer

DOI

ISSN

0032-3861

Publication Date

January 1, 2010

Volume

51

Issue

14

Start / End Page

3130 / 3138

Related Subject Headings

  • Polymers
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
 

Citation

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Safranski, D. L., Lesniewski, M. A., Caspersen, B. S., Uriarte, V. M., & Gall, K. (2010). The effect of chemistry on the polymerization, thermo-mechanical properties and degradation rate of poly(β-amino ester) networks. Polymer, 51(14), 3130–3138. https://doi.org/10.1016/j.polymer.2010.05.029
Safranski, D. L., M. A. Lesniewski, B. S. Caspersen, V. M. Uriarte, and K. Gall. “The effect of chemistry on the polymerization, thermo-mechanical properties and degradation rate of poly(β-amino ester) networks.” Polymer 51, no. 14 (January 1, 2010): 3130–38. https://doi.org/10.1016/j.polymer.2010.05.029.
Safranski DL, Lesniewski MA, Caspersen BS, Uriarte VM, Gall K. The effect of chemistry on the polymerization, thermo-mechanical properties and degradation rate of poly(β-amino ester) networks. Polymer. 2010 Jan 1;51(14):3130–8.
Safranski, D. L., et al. “The effect of chemistry on the polymerization, thermo-mechanical properties and degradation rate of poly(β-amino ester) networks.” Polymer, vol. 51, no. 14, Jan. 2010, pp. 3130–38. Scopus, doi:10.1016/j.polymer.2010.05.029.
Safranski DL, Lesniewski MA, Caspersen BS, Uriarte VM, Gall K. The effect of chemistry on the polymerization, thermo-mechanical properties and degradation rate of poly(β-amino ester) networks. Polymer. 2010 Jan 1;51(14):3130–3138.
Journal cover image

Published In

Polymer

DOI

ISSN

0032-3861

Publication Date

January 1, 2010

Volume

51

Issue

14

Start / End Page

3130 / 3138

Related Subject Headings

  • Polymers
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences