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Hepatitis C Virus Treatment: Is It Possible To Cure All Hepatitis C Virus Patients?

Publication ,  Journal Article
Muir, AJ; Naggie, S
Published in: Clin Gastroenterol Hepatol
November 2015

The recent advances in hepatitis C virus (HCV) therapeutics have brought combinations of direct acting antiviral medications that offer interferon-free, well-tolerated regimens with sustained virologic response rates greater than 90% in clinical trials for many patient groups. The successes have prompted discussions regarding cure for all patients. These regimens have already demonstrated the ability to cure previously challenging patient groups, including human immunodeficiency virus-HCV coinfection, decompensated cirrhosis, and post-liver transplantation. Limitations exist in the current portfolio of agents, with suboptimal outcomes for genotype 3 and limited data in genotypes 5 and 6. More data are urgently needed in patients with chronic kidney disease and in children. With ongoing developments, highly effective regimens for all these patient groups are within reach. To deliver HCV treatment throughout the world and particularly in low- and middle-income countries, regimens need to be affordable but also pan-genotypic, well-tolerated, and delivered once daily for 4-8 weeks. With such a regimen, cure for all patients would then hinge on the ability to identify patients with HCV infection and deliver treatment within their communities. This review will discuss the strategies that will be necessary to realize this opportunity to cure all persons with HCV infection.

Duke Scholars

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Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

November 2015

Volume

13

Issue

12

Start / End Page

2166 / 2172

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Humans
  • Hepatitis C, Chronic
  • Hepacivirus
  • Global Health
  • Genotype
  • Gastroenterology & Hepatology
  • Drug Therapy
  • Antiviral Agents
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Muir, A. J., & Naggie, S. (2015). Hepatitis C Virus Treatment: Is It Possible To Cure All Hepatitis C Virus Patients? Clin Gastroenterol Hepatol, 13(12), 2166–2172. https://doi.org/10.1016/j.cgh.2015.07.015
Muir, Andrew J., and Susanna Naggie. “Hepatitis C Virus Treatment: Is It Possible To Cure All Hepatitis C Virus Patients?Clin Gastroenterol Hepatol 13, no. 12 (November 2015): 2166–72. https://doi.org/10.1016/j.cgh.2015.07.015.
Muir AJ, Naggie S. Hepatitis C Virus Treatment: Is It Possible To Cure All Hepatitis C Virus Patients? Clin Gastroenterol Hepatol. 2015 Nov;13(12):2166–72.
Muir, Andrew J., and Susanna Naggie. “Hepatitis C Virus Treatment: Is It Possible To Cure All Hepatitis C Virus Patients?Clin Gastroenterol Hepatol, vol. 13, no. 12, Nov. 2015, pp. 2166–72. Pubmed, doi:10.1016/j.cgh.2015.07.015.
Muir AJ, Naggie S. Hepatitis C Virus Treatment: Is It Possible To Cure All Hepatitis C Virus Patients? Clin Gastroenterol Hepatol. 2015 Nov;13(12):2166–2172.
Journal cover image

Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

November 2015

Volume

13

Issue

12

Start / End Page

2166 / 2172

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Humans
  • Hepatitis C, Chronic
  • Hepacivirus
  • Global Health
  • Genotype
  • Gastroenterology & Hepatology
  • Drug Therapy
  • Antiviral Agents
  • 3202 Clinical sciences