Tissue engineered vascular grafts: Origins, development, and current strategies for clinical application.
Since the development of a dependable and durable synthetic non-autogenous vascular conduit in the mid-twentieth century, the field of vascular surgery has experienced tremendous growth. Concomitant with this growth, development in the field of bioengineering and the development of different tissue engineering techniques have expanded the armamentarium of the surgeon for treating a variety of complex cardiovascular diseases. The recent development of completely tissue engineered vascular conduits that can be implanted for clinical application is a particularly exciting development in this field. With the rapid advances in the field of tissue engineering, the great hope of the surgeon remains that this conduit will function like a true blood vessel with an intact endothelial layer, with the ability to respond to endogenous vasoactive compounds. Eventually, these engineered tissues may have the potential to supplant older organic but not truly biologic technologies, which are used currently.
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- Tissue Engineering
- Humans
- Cardiovascular Diseases
- Blood Vessel Prosthesis
- Animals
- 3101 Biochemistry and cell biology
- 1103 Clinical Sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Tissue Engineering
- Humans
- Cardiovascular Diseases
- Blood Vessel Prosthesis
- Animals
- 3101 Biochemistry and cell biology
- 1103 Clinical Sciences