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Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency.

Publication ,  Journal Article
McIntyre, RL; Kenerson, HL; Subramanian, S; Wang, SA; Kazami, M; Stapleton, HM; Yeung, RS
Published in: BMC obesity
January 2015

The potential health effects of polybrominated diphenyl ethers (PBDEs) that are widely used as flame-retardants in consumer products have been attributed, in part, to their endocrine disrupting properties. The purpose of this study is to examine the in vivo effects of an early exposure to PBDEs on the development of insulin resistance in mice.The metabolic consequences of BDE-47 in mice with varying insulin sensitivities secondary to liver-specific activation of Akt (Pten (fl/fl);Alb (Cre)) and mTORC1 (Tsc1 (fl/fl);Alb (Cre)) as well as wild-type littermates, were studied. BDE-47, a dominant congener of PBDE, was given daily (1 mg/kg/day) for six weeks by oral gavage in young mice following weaning. At the end of the exposure, there were no significant differences in total body, liver, or white adipose tissue weights between the BDE-47-treated vs. DMSO-treated mice for each respective genotype. Metabolic studies revealed significant impairment in insulin sensitivity in the BDE-47-treated Pten (fl/fl);Alb (Cre) mice, but not in wild-type or Tsc1 (fl/fl);Alb (Cre) mice. This was not accompanied by significant alterations in plasma insulin levels or hepatic triglyceride accumulation in the Pten (fl/fl);Alb (Cre) mice. The mean plasma BDE-47 level in the wild-type mice was 11.7 ± 2.9 ng/g (wet weight).Our findings indicate that BDE-47 exposure during the early post-natal period induces a mild disturbance in glucose metabolism in susceptible mice with increased baseline insulin sensitivity. These results suggest an interaction between BDE-47 and genetic factors that regulate insulin signaling, which may result in long-term consequences.

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Published In

BMC obesity

DOI

EISSN

2052-9538

ISSN

2052-9538

Publication Date

January 2015

Volume

2

Start / End Page

3

Related Subject Headings

  • 4206 Public health
  • 4203 Health services and systems
 

Citation

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McIntyre, R. L., Kenerson, H. L., Subramanian, S., Wang, S. A., Kazami, M., Stapleton, H. M., & Yeung, R. S. (2015). Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency. BMC Obesity, 2, 3. https://doi.org/10.1186/s40608-014-0031-3
McIntyre, Rebecca L., Heidi L. Kenerson, Savitha Subramanian, Shari A. Wang, Machiko Kazami, Heather M. Stapleton, and Raymond S. Yeung. “Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency.BMC Obesity 2 (January 2015): 3. https://doi.org/10.1186/s40608-014-0031-3.
McIntyre RL, Kenerson HL, Subramanian S, Wang SA, Kazami M, Stapleton HM, et al. Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency. BMC obesity. 2015 Jan;2:3.
McIntyre, Rebecca L., et al. “Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency.BMC Obesity, vol. 2, Jan. 2015, p. 3. Epmc, doi:10.1186/s40608-014-0031-3.
McIntyre RL, Kenerson HL, Subramanian S, Wang SA, Kazami M, Stapleton HM, Yeung RS. Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency. BMC obesity. 2015 Jan;2:3.
Journal cover image

Published In

BMC obesity

DOI

EISSN

2052-9538

ISSN

2052-9538

Publication Date

January 2015

Volume

2

Start / End Page

3

Related Subject Headings

  • 4206 Public health
  • 4203 Health services and systems