Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.

Publication ,  Journal Article
DeFalco, T; Potter, SJ; Williams, AV; Waller, B; Kan, MJ; Capel, B
Published in: Cell Rep
August 18, 2015

The testis produces sperm throughout the male reproductive lifespan by balancing self-renewal and differentiation of spermatogonial stem cells (SSCs). Part of the SSC niche is thought to lie outside the seminiferous tubules of the testis; however, specific interstitial components of the niche that regulate spermatogonial divisions and differentiation remain undefined. We identified distinct populations of testicular macrophages, one of which lies on the surface of seminiferous tubules, in close apposition to areas of tubules enriched for undifferentiated spermatogonia. These macrophages express spermatogonial proliferation- and differentiation-inducing factors, such as colony-stimulating factor 1 (CSF1) and enzymes involved in retinoic acid (RA) biosynthesis. We show that transient depletion of macrophages leads to a disruption in spermatogonial differentiation. These findings reveal an unexpected role for macrophages in the spermatogonial niche in the testis and raise the possibility that macrophages play previously unappreciated roles in stem/progenitor cell regulation in other tissues.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

August 18, 2015

Volume

12

Issue

7

Start / End Page

1107 / 1119

Location

United States

Related Subject Headings

  • Tretinoin
  • Testis
  • Stem Cell Niche
  • Spermatogonia
  • Spermatogenesis
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Macrophages
  • Colony-Stimulating Factors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
DeFalco, T., Potter, S. J., Williams, A. V., Waller, B., Kan, M. J., & Capel, B. (2015). Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Cell Rep, 12(7), 1107–1119. https://doi.org/10.1016/j.celrep.2015.07.015
DeFalco, Tony, Sarah J. Potter, Alyna V. Williams, Brittain Waller, Matthew J. Kan, and Blanche Capel. “Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.Cell Rep 12, no. 7 (August 18, 2015): 1107–19. https://doi.org/10.1016/j.celrep.2015.07.015.
DeFalco T, Potter SJ, Williams AV, Waller B, Kan MJ, Capel B. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Cell Rep. 2015 Aug 18;12(7):1107–19.
DeFalco, Tony, et al. “Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.Cell Rep, vol. 12, no. 7, Aug. 2015, pp. 1107–19. Pubmed, doi:10.1016/j.celrep.2015.07.015.
DeFalco T, Potter SJ, Williams AV, Waller B, Kan MJ, Capel B. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Cell Rep. 2015 Aug 18;12(7):1107–1119.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

August 18, 2015

Volume

12

Issue

7

Start / End Page

1107 / 1119

Location

United States

Related Subject Headings

  • Tretinoin
  • Testis
  • Stem Cell Niche
  • Spermatogonia
  • Spermatogenesis
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Macrophages
  • Colony-Stimulating Factors