Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy.
Publication
, Journal Article
Bothe, JR; Nikolova, EN; Eichhorn, CD; Chugh, J; Hansen, AL; Al-Hashimi, HM
Published in: Nat Methods
October 28, 2011
Many recently discovered noncoding RNAs do not fold into a single native conformation but sample many different conformations along their free-energy landscape to carry out their biological function. Here we review solution-state NMR techniques that measure the structural, kinetic and thermodynamic characteristics of RNA motions spanning picosecond to second timescales at atomic resolution, allowing unprecedented insights into the RNA dynamic structure landscape. From these studies a basic description of the RNA dynamic structure landscape is emerging, bringing new insights into how RNA structures change to carry out their function as well as applications in RNA-targeted drug discovery and RNA bioengineering.
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Published In
Nat Methods
DOI
EISSN
1548-7105
Publication Date
October 28, 2011
Volume
8
Issue
11
Start / End Page
919 / 931
Location
United States
Related Subject Headings
- Thermodynamics
- RNA
- Nuclear Magnetic Resonance, Biomolecular
- Kinetics
- Developmental Biology
- 31 Biological sciences
- 11 Medical and Health Sciences
- 10 Technology
- 06 Biological Sciences
Citation
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Chicago
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MLA
NLM
Bothe, J. R., Nikolova, E. N., Eichhorn, C. D., Chugh, J., Hansen, A. L., & Al-Hashimi, H. M. (2011). Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy. Nat Methods, 8(11), 919–931. https://doi.org/10.1038/nmeth.1735
Bothe, Jameson R., Evgenia N. Nikolova, Catherine D. Eichhorn, Jeetender Chugh, Alexandar L. Hansen, and Hashim M. Al-Hashimi. “Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy.” Nat Methods 8, no. 11 (October 28, 2011): 919–31. https://doi.org/10.1038/nmeth.1735.
Bothe JR, Nikolova EN, Eichhorn CD, Chugh J, Hansen AL, Al-Hashimi HM. Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy. Nat Methods. 2011 Oct 28;8(11):919–31.
Bothe, Jameson R., et al. “Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy.” Nat Methods, vol. 8, no. 11, Oct. 2011, pp. 919–31. Pubmed, doi:10.1038/nmeth.1735.
Bothe JR, Nikolova EN, Eichhorn CD, Chugh J, Hansen AL, Al-Hashimi HM. Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy. Nat Methods. 2011 Oct 28;8(11):919–931.
Published In
Nat Methods
DOI
EISSN
1548-7105
Publication Date
October 28, 2011
Volume
8
Issue
11
Start / End Page
919 / 931
Location
United States
Related Subject Headings
- Thermodynamics
- RNA
- Nuclear Magnetic Resonance, Biomolecular
- Kinetics
- Developmental Biology
- 31 Biological sciences
- 11 Medical and Health Sciences
- 10 Technology
- 06 Biological Sciences