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5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer.

Publication ,  Journal Article
Suppli, NP; Bukh, JD; Moffitt, TE; Caspi, A; Johansen, C; Albieri, V; Tjønneland, A; Kessing, LV; Dalton, SO
Published in: Translational psychiatry
September 2015

The serotonin-transporter-linked polymorphic region (5-HTTLPR) is one of the most extensively investigated candidates to be involved in gene-environment interaction associated with depression. Nevertheless, the interaction remains controversial. In an original study, we tested the hypothesis that risk for use of antidepressants following a diagnosis of colorectal cancer is associated with bi- and triallelic genotypes of 5-HTTLPR. In addition, in an inclusive meta-analysis, we tested the hypothesis that depression following a diagnosis of cancer is associated with biallelic 5-HTTLPR genotype. We created an exposed-only cohort of 849 colorectal cancer patients from the Danish Diet, Cancer and Health cohort study. The hypothesized association was investigated with Cox regression models and competing risk analyses. Five studies comprising a total of 1484 cancer patients were included in the meta-analysis. Nationwide registries provided information on dates of diagnosis of colorectal cancer and use of antidepressants. Unadjusted odds ratios of depression according to the biallelic 5-HTTLPR genotype were included in the meta-analysis. 5-HTTLPR genotypes were not associated with use of antidepressants after colorectal cancer. Estimated hazard ratios ranged 0.92-1.08, and we observed no statistically significant associations across biallelic and triallelic genotypes in crude as well as adjusted models. The meta-analysis showed no statistically significant associations of 5-HTTLPR biallelic genotype with depression after cancer. Our findings in an original study and a meta-analysis do not support the hypothesis of an association between the 5-HTTLPR genotype and depression after cancer.

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Published In

Translational psychiatry

DOI

EISSN

2158-3188

ISSN

2158-3188

Publication Date

September 2015

Volume

5

Start / End Page

e631

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Humans
  • Depressive Disorder
  • Colorectal Neoplasms
  • Antidepressive Agents
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services
 

Citation

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Suppli, N. P., Bukh, J. D., Moffitt, T. E., Caspi, A., Johansen, C., Albieri, V., … Dalton, S. O. (2015). 5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer. Translational Psychiatry, 5, e631. https://doi.org/10.1038/tp.2015.121
Suppli, N. P., J. D. Bukh, T. E. Moffitt, A. Caspi, C. Johansen, V. Albieri, A. Tjønneland, L. V. Kessing, and S. O. Dalton. “5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer.Translational Psychiatry 5 (September 2015): e631. https://doi.org/10.1038/tp.2015.121.
Suppli NP, Bukh JD, Moffitt TE, Caspi A, Johansen C, Albieri V, et al. 5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer. Translational psychiatry. 2015 Sep;5:e631.
Suppli, N. P., et al. “5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer.Translational Psychiatry, vol. 5, Sept. 2015, p. e631. Epmc, doi:10.1038/tp.2015.121.
Suppli NP, Bukh JD, Moffitt TE, Caspi A, Johansen C, Albieri V, Tjønneland A, Kessing LV, Dalton SO. 5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer. Translational psychiatry. 2015 Sep;5:e631.

Published In

Translational psychiatry

DOI

EISSN

2158-3188

ISSN

2158-3188

Publication Date

September 2015

Volume

5

Start / End Page

e631

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Humans
  • Depressive Disorder
  • Colorectal Neoplasms
  • Antidepressive Agents
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1117 Public Health and Health Services