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Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix.

Publication ,  Journal Article
Ng, AH; Omelon, S; Variola, F; Allo, B; Willett, TL; Alman, BA; Grynpas, MD
Published in: J Bone Miner Res
February 2016

Adynamic bone is the most frequent type of bone lesion in patients with chronic kidney disease; long-term use of antiresorptive therapy may also lead to the adynamic bone condition. The hallmark of adynamic bone is a loss of bone turnover, and a major clinical concern of adynamic bone is diminished bone quality and an increase in fracture risk. Our current study aims to investigate how bone quality changes with age in our previously established mouse model of adynamic bone. Young and old mice (4 months old and 16 months old, respectively) were used in this study. Col2.3Δtk (DTK) mice were treated with ganciclovir and pamidronate to create the adynamic bone condition. Bone quality was evaluated using established techniques including bone histomorphometry, microcomputed tomography, quantitative backscattered electron imaging, and biomechanical testing. Changes in mineral and matrix properties were examined by powder X-ray diffraction and Raman spectroscopy. Aging controls had a natural decline in bone formation and resorption with a corresponding deterioration in trabecular bone structure. Bone turnover was severely blunted at all ages in adynamic animals, which preserved trabecular bone loss normally associated with aging. However, the preservation of trabecular bone mass and structure in old adynamic mice did not rescue deterioration of bone mechanical properties. There was also a decrease in cortical bone toughness in old adynamic mice that was accompanied by a more mature collagen matrix and longer bone crystals. Little is known about the effects of metabolic bone disease on bone fracture resistance. We observed an age-related decrease in bone toughness that was worsened by the adynamic condition, and this decrease may be due to material level changes at the tissue level. Our mouse model may be useful in the investigation of the mechanisms involved in fractures occurring in elderly patients on antiresorptive therapy who have very low bone turnover.

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Published In

J Bone Miner Res

DOI

EISSN

1523-4681

Publication Date

February 2016

Volume

31

Issue

2

Start / End Page

369 / 379

Location

England

Related Subject Headings

  • Mice, Transgenic
  • Mice
  • Immobilization
  • Hypokinesia
  • Humans
  • Fractures, Bone
  • Collagen
  • Bone Density
  • Animals
  • Anatomy & Morphology
 

Citation

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ICMJE
MLA
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Ng, A. H., Omelon, S., Variola, F., Allo, B., Willett, T. L., Alman, B. A., & Grynpas, M. D. (2016). Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix. J Bone Miner Res, 31(2), 369–379. https://doi.org/10.1002/jbmr.2702
Ng, Adeline H., Sidney Omelon, Fabio Variola, Bedilu Allo, Thomas L. Willett, Benjamin A. Alman, and Marc D. Grynpas. “Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix.J Bone Miner Res 31, no. 2 (February 2016): 369–79. https://doi.org/10.1002/jbmr.2702.
Ng AH, Omelon S, Variola F, Allo B, Willett TL, Alman BA, et al. Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix. J Bone Miner Res. 2016 Feb;31(2):369–79.
Ng, Adeline H., et al. “Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix.J Bone Miner Res, vol. 31, no. 2, Feb. 2016, pp. 369–79. Pubmed, doi:10.1002/jbmr.2702.
Ng AH, Omelon S, Variola F, Allo B, Willett TL, Alman BA, Grynpas MD. Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix. J Bone Miner Res. 2016 Feb;31(2):369–379.
Journal cover image

Published In

J Bone Miner Res

DOI

EISSN

1523-4681

Publication Date

February 2016

Volume

31

Issue

2

Start / End Page

369 / 379

Location

England

Related Subject Headings

  • Mice, Transgenic
  • Mice
  • Immobilization
  • Hypokinesia
  • Humans
  • Fractures, Bone
  • Collagen
  • Bone Density
  • Animals
  • Anatomy & Morphology