Electrical Diseases of the Heart Volume 2 Diagnosis and Treatment Second Edition
Clinical trials in sudden cardiac death prevention: Principles and endpoints
Publication
, Chapter
Kosinski, AS
January 1, 2013
A properly designed and conducted randomized clinical trial is the most objective approach for definitive comparison of medical therapies. However, a clinical trial is a complex collaborative undertaking and requires substantial multidisciplinary planning efforts. This chapter presents the main components of a randomized trial and discusses the essential statistical concepts relevant in a trial design. The primary result and summary of statistical power, analysis, and the follow-up approach of the four recently completed pivotal clinical trials pertinent to the prevention of sudden cardiac death are summarized.
Duke Scholars
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Kosinski, A. S. (2013). Clinical trials in sudden cardiac death prevention: Principles and endpoints. In Electrical Diseases of the Heart Volume 2 Diagnosis and Treatment Second Edition (pp. 487–493). https://doi.org/10.1007/978-1-4471-4978-1_31
Kosinski, A. S. “Clinical trials in sudden cardiac death prevention: Principles and endpoints.” In Electrical Diseases of the Heart Volume 2 Diagnosis and Treatment Second Edition, 487–93, 2013. https://doi.org/10.1007/978-1-4471-4978-1_31.
Kosinski AS. Clinical trials in sudden cardiac death prevention: Principles and endpoints. In: Electrical Diseases of the Heart Volume 2 Diagnosis and Treatment Second Edition. 2013. p. 487–93.
Kosinski, A. S. “Clinical trials in sudden cardiac death prevention: Principles and endpoints.” Electrical Diseases of the Heart Volume 2 Diagnosis and Treatment Second Edition, 2013, pp. 487–93. Scopus, doi:10.1007/978-1-4471-4978-1_31.
Kosinski AS. Clinical trials in sudden cardiac death prevention: Principles and endpoints. Electrical Diseases of the Heart Volume 2 Diagnosis and Treatment Second Edition. 2013. p. 487–493.