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Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life.

Publication ,  Journal Article
Anderson, LM; Allen, TM; Thornburg, CD; Bonner, MJ
Published in: J Pediatr Hematol Oncol
November 2015

Children with sickle cell disease (SCD) report fatigue in addition to acute and chronic pain, which can decrease overall health-related quality of life (HRQL). The primary objective of the current study was to investigate the relationship between fatigue and HRQL. Given limited prior research, secondary objectives included investigation of associations between fatigue and functional outcomes, including child neurocognitive and social-emotional functioning. Children aged 8 to 16 years (N=32) and a caregiver completed measures of fatigue, HRQL, pain, and neurocognitive and social-emotional functioning. Controlling for pain and number of SCD-related hospitalizations, hierarchical linear regression models were used to determine the impact of child-reported and parent-reported fatigue on child HRQL. Correlational analyses were used to explore the relationship between fatigue and additional child outcomes. Data indicated that children with SCD experience clinically relevant levels of fatigue, which independently predicts lower HRQL. Fatigue was also associated with lower working memory, executive functioning, and higher levels of internalizing symptoms. Given its observed impact on HRQL and relationship to functional outcomes, fatigue may be an important target of clinical, home, or school interventions. This practice may attenuate the burden of fatigue in these patients, and in turn, help improve the quality of life of children living with SCD.

Duke Scholars

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

November 2015

Volume

37

Issue

8

Start / End Page

584 / 589

Location

United States

Related Subject Headings

  • Social Behavior
  • Severity of Illness Index
  • Self Report
  • Quality of Life
  • Parents
  • Pain Measurement
  • Oncology & Carcinogenesis
  • Memory, Short-Term
  • Memory Disorders
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Anderson, L. M., Allen, T. M., Thornburg, C. D., & Bonner, M. J. (2015). Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life. J Pediatr Hematol Oncol, 37(8), 584–589. https://doi.org/10.1097/MPH.0000000000000431
Anderson, Lindsay M., Taryn M. Allen, Courtney D. Thornburg, and Melanie J. Bonner. “Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life.J Pediatr Hematol Oncol 37, no. 8 (November 2015): 584–89. https://doi.org/10.1097/MPH.0000000000000431.
Anderson LM, Allen TM, Thornburg CD, Bonner MJ. Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life. J Pediatr Hematol Oncol. 2015 Nov;37(8):584–9.
Anderson, Lindsay M., et al. “Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life.J Pediatr Hematol Oncol, vol. 37, no. 8, Nov. 2015, pp. 584–89. Pubmed, doi:10.1097/MPH.0000000000000431.
Anderson LM, Allen TM, Thornburg CD, Bonner MJ. Fatigue in Children With Sickle Cell Disease: Association With Neurocognitive and Social-Emotional Functioning and Quality of Life. J Pediatr Hematol Oncol. 2015 Nov;37(8):584–589.

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

November 2015

Volume

37

Issue

8

Start / End Page

584 / 589

Location

United States

Related Subject Headings

  • Social Behavior
  • Severity of Illness Index
  • Self Report
  • Quality of Life
  • Parents
  • Pain Measurement
  • Oncology & Carcinogenesis
  • Memory, Short-Term
  • Memory Disorders
  • Male