Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies.

Influenza B virus is a human pathogen responsible for significant health and economic burden. Research into this pathogen has been limited by the lack of reporter viruses. Here we describe the development of both a replication-competent fluorescent influenza B reporter virus and bioluminescent influenza B reporter virus. Furthermore, we demonstrate these reporter viruses can be used to quickly monitor viral growth and permit the rapid screening of antiviral compounds and neutralizing antibodies.

Duke Scholars

Author Nicholas Scott Heaton Molecular Genetics and Microbiology