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Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis.

Publication ,  Journal Article
Al-Herz, W; Notarangelo, LD; Sadek, A; Buckley, R; USIDNET Consortium,
Published in: Clin Immunol
December 2015

AIM: To compare different variables among (S)CID patients diagnosed in the USA and Kuwait. METHODS: Review of patients registered in The US Immune Deficiency Network registry or Kuwait National PID Registry between 2004 and 2014. RESULTS: Totals of 98 and 69 (S)CID patients were registered during the study period in the USIDNET registry and the KNPIDR, respectively. The average annual incidence rate for the period 2004-2014 of (S)CID in children in Kuwait was 13.01/100,000 children, with an estimated occurrence of 1/7500 live births. There were differences between the two countries in the following variables: age at onset and diagnosis, family history of (S)CID, parental consanguinity, and outcome. More than 14% of (S)CID patients from USIDNET registry were diagnosed through newborn screening. CONCLUSIONS: Patients' characteristics and molecular causes of S(CID) are different between USA and Kuwait. NBS for SCID should be started in countries where the incidence of (S)CID is high.

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Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

December 2015

Volume

161

Issue

2

Start / End Page

170 / 173

Location

United States

Related Subject Headings

  • United States
  • Registries
  • Pathology, Molecular
  • Neonatal Screening
  • Kuwait
  • Infant, Newborn
  • Immunology
  • Immunologic Deficiency Syndromes
  • Humans
  • Child
 

Citation

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Chicago
ICMJE
MLA
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Al-Herz, W., Notarangelo, L. D., Sadek, A., Buckley, R., & USIDNET Consortium, . (2015). Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis. Clin Immunol, 161(2), 170–173. https://doi.org/10.1016/j.clim.2015.07.013
Al-Herz, Waleed, Luigi D. Notarangelo, Ali Sadek, Rebecca Buckley, and Rebecca USIDNET Consortium. “Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis.Clin Immunol 161, no. 2 (December 2015): 170–73. https://doi.org/10.1016/j.clim.2015.07.013.
Al-Herz W, Notarangelo LD, Sadek A, Buckley R, USIDNET Consortium. Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis. Clin Immunol. 2015 Dec;161(2):170–3.
Al-Herz, Waleed, et al. “Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis.Clin Immunol, vol. 161, no. 2, Dec. 2015, pp. 170–73. Pubmed, doi:10.1016/j.clim.2015.07.013.
Al-Herz W, Notarangelo LD, Sadek A, Buckley R, USIDNET Consortium. Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis. Clin Immunol. 2015 Dec;161(2):170–173.
Journal cover image

Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

December 2015

Volume

161

Issue

2

Start / End Page

170 / 173

Location

United States

Related Subject Headings

  • United States
  • Registries
  • Pathology, Molecular
  • Neonatal Screening
  • Kuwait
  • Infant, Newborn
  • Immunology
  • Immunologic Deficiency Syndromes
  • Humans
  • Child