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Coagulation in Liver Disease.

Publication ,  Journal Article
Hoffman, M
Published in: Semin Thromb Hemost
July 2015

The liver plays a key role in hemostasis as the site of synthesis of many of the proteins involved in the coagulation, antithrombotic and fibrinolytic systems that interact to both establish hemostasis, and preventing thrombosis. The common laboratory tests, prothrombin time (PT) and activated partial thromboplastin time (aPTT), evolved from studies of plasma clotting in test tubes. Such studies laid the basis for the coagulation cascade model of hemostasis. However, thought has evolved to place a greater emphasis on the active roles of cells in localizing and regulating hemostasis. The PT and aPTT do not reflect the roles of cellular elements in hemostasis, nor do they reflect the crucial roles of antithrombotic and fibrinolytic systems. Thus, though the PT may indeed reflect the synthetic capacity of the liver, it does not accurately reflect the risk of bleeding or thrombosis in patients with liver failure.

Duke Scholars

Published In

Semin Thromb Hemost

DOI

EISSN

1098-9064

Publication Date

July 2015

Volume

41

Issue

5

Start / End Page

447 / 454

Location

United States

Related Subject Headings

  • Prothrombin Time
  • Liver Diseases
  • Humans
  • Hemostasis
  • Fibrinolysis
  • Cardiovascular System & Hematology
  • Blood Coagulation
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoffman, M. (2015). Coagulation in Liver Disease. Semin Thromb Hemost, 41(5), 447–454. https://doi.org/10.1055/s-0035-1550435
Hoffman, Maureane. “Coagulation in Liver Disease.Semin Thromb Hemost 41, no. 5 (July 2015): 447–54. https://doi.org/10.1055/s-0035-1550435.
Hoffman M. Coagulation in Liver Disease. Semin Thromb Hemost. 2015 Jul;41(5):447–54.
Hoffman, Maureane. “Coagulation in Liver Disease.Semin Thromb Hemost, vol. 41, no. 5, July 2015, pp. 447–54. Pubmed, doi:10.1055/s-0035-1550435.
Hoffman M. Coagulation in Liver Disease. Semin Thromb Hemost. 2015 Jul;41(5):447–454.
Journal cover image

Published In

Semin Thromb Hemost

DOI

EISSN

1098-9064

Publication Date

July 2015

Volume

41

Issue

5

Start / End Page

447 / 454

Location

United States

Related Subject Headings

  • Prothrombin Time
  • Liver Diseases
  • Humans
  • Hemostasis
  • Fibrinolysis
  • Cardiovascular System & Hematology
  • Blood Coagulation
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences