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Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.

Publication ,  Journal Article
Reynolds, AE; Kuraoka, M; Kelsoe, G
Published in: J Immunol
January 1, 2015

Natural IgM is constitutively present in the serum, where it aids in the early control of viral and bacterial expansions. Natural IgM also plays a significant role in the prevention of autoimmune disease by promoting the clearance of cellular debris. Nevertheless, the origins of natural IgM have not been precisely defined. Previous studies focused on the role of CD5(+) B1 cells in the production of natural IgM, but we show in this article that a discrete population of CD5(-) IgM plasmablasts and plasma cells in the bone marrow (BM) produces the majority of serum IgM in resting mice. These Ab-secreting cells (ASC) originate from peritoneal cavity-resident cells, because transfer of peritoneal cells completely restores serum IgM and the specific compartment of BM ASC in Rag1-deficient mice. We show that BM natural IgM ASC arise from a fetal-lineage progenitor that is neither B1a nor B1b, and that this IgM ASC compartment contains a substantial fraction of long-lived plasma cells that do not occupy the IgG plasma cell survival niche in the BM; instead, they are supported by IL-5. In summary, we identified the primary source of natural IgM and showed that these ASC are maintained long-term in a unique survival niche within the BM.

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Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

January 1, 2015

Volume

194

Issue

1

Start / End Page

231 / 242

Location

United States

Related Subject Headings

  • V(D)J Recombination
  • Sequence Analysis, DNA
  • Plasma Cells
  • Peritoneal Cavity
  • Molecular Sequence Data
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Interleukin-6
 

Citation

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Reynolds, A. E., Kuraoka, M., & Kelsoe, G. (2015). Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow. J Immunol, 194(1), 231–242. https://doi.org/10.4049/jimmunol.1401203
Reynolds, Alexander E., Masayuki Kuraoka, and Garnett Kelsoe. “Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.J Immunol 194, no. 1 (January 1, 2015): 231–42. https://doi.org/10.4049/jimmunol.1401203.
Reynolds AE, Kuraoka M, Kelsoe G. Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow. J Immunol. 2015 Jan 1;194(1):231–42.
Reynolds, Alexander E., et al. “Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.J Immunol, vol. 194, no. 1, Jan. 2015, pp. 231–42. Pubmed, doi:10.4049/jimmunol.1401203.
Reynolds AE, Kuraoka M, Kelsoe G. Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow. J Immunol. 2015 Jan 1;194(1):231–242.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

January 1, 2015

Volume

194

Issue

1

Start / End Page

231 / 242

Location

United States

Related Subject Headings

  • V(D)J Recombination
  • Sequence Analysis, DNA
  • Plasma Cells
  • Peritoneal Cavity
  • Molecular Sequence Data
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Interleukin-6