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Visual impairment in an optineurin mouse model of primary open-angle glaucoma.

Publication ,  Journal Article
Tseng, HC; Riday, TT; McKee, C; Braine, CE; Bomze, H; Barak, I; Marean-Reardon, C; John, SWM; Philpot, BD; Ehlers, MD
Published in: Neurobiol Aging
June 2015

Primary open-angle glaucoma (POAG) is characterized by progressive neurodegeneration of retinal ganglion cells (RGCs). Why RGCs degenerate in low-pressure POAG remains poorly understood. To gain mechanistic insights, we developed a novel mouse model based on a mutation in human optineurin associated with hereditary, low-pressure POAG. This mouse improves the design and phenotype of currently available optineurin mice, which showed high global overexpression. Although both 18-month-old optineurin and nontransgenic control mice showed an age-related decrease in healthy axons and RGCs, the expression of mutant optineurin enhanced axonal degeneration and decreased RGC survival. Mouse visual function was determined using visual evoked potentials, which revealed specific visual impairment in contrast sensitivity. The E50K optineurin transgenic mouse described here exhibited clinical features of POAG and may be useful for mechanistic dissection of POAG and therapeutic development.

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Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

June 2015

Volume

36

Issue

6

Start / End Page

2201 / 2212

Location

United States

Related Subject Headings

  • Vision Disorders
  • Retinal Ganglion Cells
  • Neurology & Neurosurgery
  • Nerve Degeneration
  • Mutation
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Membrane Transport Proteins
  • Humans
  • Glaucoma, Open-Angle
 

Citation

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Chicago
ICMJE
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Tseng, H. C., Riday, T. T., McKee, C., Braine, C. E., Bomze, H., Barak, I., … Ehlers, M. D. (2015). Visual impairment in an optineurin mouse model of primary open-angle glaucoma. Neurobiol Aging, 36(6), 2201–2212. https://doi.org/10.1016/j.neurobiolaging.2015.02.012
Tseng, Henry C., Thorfinn T. Riday, Celia McKee, Catherine E. Braine, Howard Bomze, Ian Barak, Carrie Marean-Reardon, Simon W. M. John, Benjamin D. Philpot, and Michael D. Ehlers. “Visual impairment in an optineurin mouse model of primary open-angle glaucoma.Neurobiol Aging 36, no. 6 (June 2015): 2201–12. https://doi.org/10.1016/j.neurobiolaging.2015.02.012.
Tseng HC, Riday TT, McKee C, Braine CE, Bomze H, Barak I, et al. Visual impairment in an optineurin mouse model of primary open-angle glaucoma. Neurobiol Aging. 2015 Jun;36(6):2201–12.
Tseng, Henry C., et al. “Visual impairment in an optineurin mouse model of primary open-angle glaucoma.Neurobiol Aging, vol. 36, no. 6, June 2015, pp. 2201–12. Pubmed, doi:10.1016/j.neurobiolaging.2015.02.012.
Tseng HC, Riday TT, McKee C, Braine CE, Bomze H, Barak I, Marean-Reardon C, John SWM, Philpot BD, Ehlers MD. Visual impairment in an optineurin mouse model of primary open-angle glaucoma. Neurobiol Aging. 2015 Jun;36(6):2201–2212.
Journal cover image

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

June 2015

Volume

36

Issue

6

Start / End Page

2201 / 2212

Location

United States

Related Subject Headings

  • Vision Disorders
  • Retinal Ganglion Cells
  • Neurology & Neurosurgery
  • Nerve Degeneration
  • Mutation
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Membrane Transport Proteins
  • Humans
  • Glaucoma, Open-Angle