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Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.

Publication ,  Journal Article
Baddour, LM; Wilson, WR; Bayer, AS; Fowler, VG; Tleyjeh, IM; Rybak, MJ; Barsic, B; Lockhart, PB; Gewitz, MH; Levison, ME; Bolger, AF; Fink, AM ...
Published in: Circulation
October 13, 2015

BACKGROUND: Infective endocarditis is a potentially lethal disease that has undergone major changes in both host and pathogen. The epidemiology of infective endocarditis has become more complex with today's myriad healthcare-associated factors that predispose to infection. Moreover, changes in pathogen prevalence, in particular a more common staphylococcal origin, have affected outcomes, which have not improved despite medical and surgical advances. METHODS AND RESULTS: This statement updates the 2005 iteration, both of which were developed by the American Heart Association under the auspices of the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease of the Young. It includes an evidence-based system for diagnostic and treatment recommendations used by the American College of Cardiology and the American Heart Association for treatment recommendations. CONCLUSIONS: Infective endocarditis is a complex disease, and patients with this disease generally require management by a team of physicians and allied health providers with a variety of areas of expertise. The recommendations provided in this document are intended to assist in the management of this uncommon but potentially deadly infection. The clinical variability and complexity in infective endocarditis, however, dictate that these recommendations be used to support and not supplant decisions in individual patient management.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

October 13, 2015

Volume

132

Issue

15

Start / End Page

1435 / 1486

Location

United States

Related Subject Headings

  • Streptococcal Infections
  • Staphylococcal Infections
  • Risk Factors
  • Rheumatic Heart Disease
  • Prosthesis-Related Infections
  • Humans
  • Heart Valve Prosthesis
  • Endocarditis
  • Diagnostic Techniques, Cardiovascular
  • Cardiovascular System & Hematology
 

Citation

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Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G., Tleyjeh, I. M., Rybak, M. J., … American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council, . (2015). Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation, 132(15), 1435–1486. https://doi.org/10.1161/CIR.0000000000000296
Baddour, Larry M., Walter R. Wilson, Arnold S. Bayer, Vance G. Fowler, Imad M. Tleyjeh, Michael J. Rybak, Bruno Barsic, et al. “Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.Circulation 132, no. 15 (October 13, 2015): 1435–86. https://doi.org/10.1161/CIR.0000000000000296.
Baddour, Larry M., et al. “Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.Circulation, vol. 132, no. 15, Oct. 2015, pp. 1435–86. Pubmed, doi:10.1161/CIR.0000000000000296.
Baddour LM, Wilson WR, Bayer AS, Fowler VG, Tleyjeh IM, Rybak MJ, Barsic B, Lockhart PB, Gewitz MH, Levison ME, Bolger AF, Steckelberg JM, Baltimore RS, Fink AM, O’Gara P, Taubert KA, American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation. 2015 Oct 13;132(15):1435–1486.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

October 13, 2015

Volume

132

Issue

15

Start / End Page

1435 / 1486

Location

United States

Related Subject Headings

  • Streptococcal Infections
  • Staphylococcal Infections
  • Risk Factors
  • Rheumatic Heart Disease
  • Prosthesis-Related Infections
  • Humans
  • Heart Valve Prosthesis
  • Endocarditis
  • Diagnostic Techniques, Cardiovascular
  • Cardiovascular System & Hematology